FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3139074594> ?p ?o ?g. }

• W3139074594 endingPage "337" @default.
• W3139074594 startingPage "337" @default.
• W3139074594 abstract "Marine natural products (MNPs) have been an important and rich source for antimicrobial drug discovery and an effective alternative to control drug resistant infections. Herein, we report bioassay guided fractionation of marine extracts from sponges Lendenfeldia, Ircinia and Dysidea that led us to identify novel compounds with antimicrobial properties. Tertiary amines or quaternary amine salts: aniline 1, benzylamine 2, tertiary amine 3 and 4, and quaternary amine salt 5, along with three known compounds (6–8) were isolated from a crude extract and MeOH eluent marine extracts. The antibiotic activities of the compounds, and their isolation as natural products have not been reported before. Using tandem mass spectrometry (MS) analysis, potential structures of the bioactive fractions were assigned, leading to the hit validation of potential compounds through synthesis, and commercially available compounds. This method is a novel strategy to overcome insufficient quantities of pure material (NPs) for drug discovery and development which is a big challenge for pharmaceutical companies. The antibacterial screening of the marine extracts has shown several of the compounds exhibited potent in-vitro antibacterial activity, especially against methicillin-resistant Staphylococcus aureus (MRSA) with minimum inhibitory concentration (MIC) values between 15.6 to 62.5 microg mL−1. Herein, we also report structure activity relationships of a diverse range of commercial structurally similar compounds. The structure-activity relationships (SAR) results demonstrate that modification of the amines through linear chain length, and inclusion of aromatic rings, modifies the observed antimicrobial activity. Several commercially available compounds, which are structurally related to the discovered molecules, showed broad-spectrum antimicrobial activity against different test pathogens with a MIC range of 50 to 0.01 µM. The results of cross-referencing antimicrobial activity and cytotoxicity establish that these compounds are promising potential molecules, with a favourable therapeutic index for antimicrobial drug development. Additionally, the SAR studies show that simplified analogues of the isolated compounds have increased bioactivity." @default.
• W3139074594 created "2021-03-29" @default.
• W3139074594 creator A5047957808 @default.
• W3139074594 creator A5053567835 @default.
• W3139074594 date "2021-03-22" @default.
• W3139074594 modified "2023-09-25" @default.
• W3139074594 title "Identification of Bioactive Compounds from Marine Natural Products and Exploration of Structure-Activity Relationships (SAR)" @default.
• W3139074594 cites W1487271490 @default.
• W3139074594 cites W1820911479 @default.
• W3139074594 cites W1966147121 @default.
• W3139074594 cites W1992084711 @default.
• W3139074594 cites W1999893599 @default.
• W3139074594 cites W2011257176 @default.
• W3139074594 cites W2015169841 @default.
• W3139074594 cites W2022382089 @default.
• W3139074594 cites W2025061464 @default.
• W3139074594 cites W2037106429 @default.
• W3139074594 cites W2044296969 @default.
• W3139074594 cites W2044944453 @default.
• W3139074594 cites W2047496634 @default.
• W3139074594 cites W2065921894 @default.
• W3139074594 cites W2070847413 @default.
• W3139074594 cites W2072920950 @default.
• W3139074594 cites W2086756671 @default.
• W3139074594 cites W2088226047 @default.
• W3139074594 cites W2089138822 @default.
• W3139074594 cites W2097393422 @default.
• W3139074594 cites W2099983582 @default.
• W3139074594 cites W2101257438 @default.
• W3139074594 cites W2102838769 @default.
• W3139074594 cites W2120350838 @default.
• W3139074594 cites W2127310510 @default.
• W3139074594 cites W2138278616 @default.
• W3139074594 cites W2146942065 @default.
• W3139074594 cites W2169582846 @default.
• W3139074594 cites W2256742438 @default.
• W3139074594 cites W2267287632 @default.
• W3139074594 cites W2314510665 @default.
• W3139074594 cites W2346531815 @default.
• W3139074594 cites W2398621244 @default.
• W3139074594 cites W2491904109 @default.
• W3139074594 cites W2524098322 @default.
• W3139074594 cites W2588188772 @default.
• W3139074594 cites W2611021352 @default.
• W3139074594 cites W2740677521 @default.
• W3139074594 cites W2745268249 @default.
• W3139074594 cites W2750635679 @default.
• W3139074594 cites W2794044688 @default.
• W3139074594 cites W2914431674 @default.
• W3139074594 cites W2915934553 @default.
• W3139074594 cites W2952876965 @default.
• W3139074594 cites W2953141042 @default.
• W3139074594 cites W3108749129 @default.
• W3139074594 cites W4211018043 @default.
• W3139074594 cites W4211082868 @default.
• W3139074594 doi "https://doi.org/10.3390/antibiotics10030337" @default.
• W3139074594 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8004798" @default.
• W3139074594 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33810102" @default.
• W3139074594 hasPublicationYear "2021" @default.
• W3139074594 type Work @default.
• W3139074594 sameAs 3139074594 @default.
• W3139074594 citedByCount "6" @default.
• W3139074594 countsByYear W31390745942022 @default.
• W3139074594 countsByYear W31390745942023 @default.
• W3139074594 crossrefType "journal-article" @default.
• W3139074594 hasAuthorship W3139074594A5047957808 @default.
• W3139074594 hasAuthorship W3139074594A5053567835 @default.
• W3139074594 hasBestOaLocation W31390745941 @default.
• W3139074594 hasConcept C131779359 @default.
• W3139074594 hasConcept C178790620 @default.
• W3139074594 hasConcept C185592680 @default.
• W3139074594 hasConcept C21951064 @default.
• W3139074594 hasConcept C2780104969 @default.
• W3139074594 hasConcept C4937899 @default.
• W3139074594 hasConcept C523546767 @default.
• W3139074594 hasConcept C54355233 @default.
• W3139074594 hasConcept C55493867 @default.
• W3139074594 hasConcept C74187038 @default.
• W3139074594 hasConcept C86803240 @default.
• W3139074594 hasConceptScore W3139074594C131779359 @default.
• W3139074594 hasConceptScore W3139074594C178790620 @default.
• W3139074594 hasConceptScore W3139074594C185592680 @default.
• W3139074594 hasConceptScore W3139074594C21951064 @default.
• W3139074594 hasConceptScore W3139074594C2780104969 @default.
• W3139074594 hasConceptScore W3139074594C4937899 @default.
• W3139074594 hasConceptScore W3139074594C523546767 @default.
• W3139074594 hasConceptScore W3139074594C54355233 @default.
• W3139074594 hasConceptScore W3139074594C55493867 @default.
• W3139074594 hasConceptScore W3139074594C74187038 @default.
• W3139074594 hasConceptScore W3139074594C86803240 @default.
• W3139074594 hasIssue "3" @default.
• W3139074594 hasLocation W31390745941 @default.
• W3139074594 hasLocation W31390745942 @default.
• W3139074594 hasLocation W31390745943 @default.
• W3139074594 hasOpenAccess W3139074594 @default.
• W3139074594 hasPrimaryLocation W31390745941 @default.
• W3139074594 hasRelatedWork W1845624145 @default.
• W3139074594 hasRelatedWork W1987755785 @default.

• next