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• W3139075290 endingPage "3369" @default.
• W3139075290 startingPage "3369" @default.
• W3139075290 abstract "Genetic characteristics of blood donors may impact the storability of blood products. Despite higher basal stress, red blood cells (RBCs) from eligible donors that are heterozygous for beta-thalassemia traits (βThal+) possess a differential nitrogen-related metabolism, and cope better with storage stress compared to the control. Nevertheless, not much is known about how storage impacts the proteome of membrane and extracellular vesicles (EVs) in βThal+. For this purpose, RBC units from twelve βThal+ donors were studied through proteomics, immunoblotting, electron microscopy, and functional ELISA assays, versus units from sex- and aged-matched controls. βThal+ RBCs exhibited less irreversible shape modifications. Their membrane proteome was characterized by different levels of structural, lipid raft, transport, chaperoning, redox, and enzyme components. The most prominent findings include the upregulation of myosin proteoforms, arginase-1, heat shock proteins, and protein kinases, but the downregulation of nitrogen-related transporters. The unique membrane proteome was also mirrored, in part, to that of βThal+ EVs. Network analysis revealed interesting connections of membrane vesiculation with storage and stress hemolysis, along with proteome control modulators of the RBC membrane. Our findings, which are in line with the mild but consistent oxidative stress these cells experience in vivo, provide insight into the physiology and aging of stored βThal+ RBCs." @default.
• W3139075290 created "2021-03-29" @default.
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• W3139075290 date "2021-03-25" @default.
• W3139075290 modified "2023-10-15" @default.
• W3139075290 title "Proteome of Stored RBC Membrane and Vesicles from Heterozygous Beta Thalassemia Donors" @default.
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• W3139075290 cites W1984099413 @default.
• W3139075290 cites W1989185384 @default.
• W3139075290 cites W1994031108 @default.
• W3139075290 cites W1995509779 @default.
• W3139075290 cites W1997023449 @default.
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• W3139075290 doi "https://doi.org/10.3390/ijms22073369" @default.
• W3139075290 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8037027" @default.
• W3139075290 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33806028" @default.
• W3139075290 hasPublicationYear "2021" @default.
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