FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3139093071> ?p ?o ?g. }

• W3139093071 endingPage "152088" @default.
• W3139093071 startingPage "152088" @default.
• W3139093071 abstract "Dendritic cells (DC) and T-cells are mediators of CTL-responses. Autologous (from patients with acute myeloid leukaemia (AML) or myelodysplasia (MDS)) or allogeneic (donor)-T-cells stimulated by DCleu, gain an efficient lysis of naive blasts, although not in every case. CXCL8, -9, -10, CCL2, -5 and Interleukin (IL-12) were quantified by Cytometric Bead Array (CBA) in supernatants from 5 DC-generating methods and correlated with AML-/MDS-patients' serum-values, DC-/T-cell-interactions/antileukemic T-cell-reactions after mixed lymphocyte culture (MLC) and patients' clinical course. The blast-lytic activity of T-cells stimulated with DC or mononuclear cells (MNC) was quantified in a cytotoxicity assay. Despite great variations of chemokine-levels, correlations with post-stimulation (after stimulating T-cells with DC in MLC) improved antileukemic T-cell activity were seen: higher released chemokine-values correlated with improved T-cells' antileukemic activity (compared to stimulation with blast-containing MNC) - whereas with respect to the corresponding serum values higher CXCL8-, -9-, and -10- but lower CCL5- and -2-release correlated with improved antileukemic activity of DC-stimulated (vs. blast-stimulated) T-cells. In DC-culture supernatants higher chemokine-values correlated with post-stimulation improved antileukemic T-cell reactivity, whereas higher serum-values of CXCL8, -9, and -10 but lower serum-values of CCL5 and -2 correlated with post-stimulation improved antileukemic T-cell-reactivity. In a context of 'DC'-stimulation (vs serum) this might point to a change of (CCL5 and -2-associated) functionality from a more 'inflammatory' or 'tumor-promoting' to a more 'antitumor'-reactive functionality. This knowledge could contribute to develop immune-modifying strategies that promote antileukemic (adaptive) immune-responses." @default.
• W3139093071 created "2021-03-29" @default.
• W3139093071 creator A5001890886 @default.
• W3139093071 creator A5003992313 @default.
• W3139093071 creator A5006284475 @default.
• W3139093071 creator A5007079069 @default.
• W3139093071 creator A5013668398 @default.
• W3139093071 creator A5016982147 @default.
• W3139093071 creator A5026106615 @default.
• W3139093071 creator A5028512612 @default.
• W3139093071 creator A5032050812 @default.
• W3139093071 creator A5037337303 @default.
• W3139093071 creator A5041948122 @default.
• W3139093071 creator A5051809636 @default.
• W3139093071 creator A5054393582 @default.
• W3139093071 creator A5069893847 @default.
• W3139093071 creator A5086770944 @default.
• W3139093071 date "2021-05-01" @default.
• W3139093071 modified "2023-09-27" @default.
• W3139093071 title "Conversion of AML-blasts to leukemia-derived dendritic cells (DCleu) in ‘DC-culture-media’ shifts correlations of released chemokines with antileukemic T-cell reactions" @default.
• W3139093071 cites W1501307453 @default.
• W3139093071 cites W1514269427 @default.
• W3139093071 cites W1543572242 @default.
• W3139093071 cites W1895528512 @default.
• W3139093071 cites W1965781942 @default.
• W3139093071 cites W1968848897 @default.
• W3139093071 cites W1972588306 @default.
• W3139093071 cites W1975558291 @default.
• W3139093071 cites W1985396428 @default.
• W3139093071 cites W1991443085 @default.
• W3139093071 cites W1995356106 @default.
• W3139093071 cites W1996242150 @default.
• W3139093071 cites W1996436013 @default.
• W3139093071 cites W1998965387 @default.
• W3139093071 cites W1999681001 @default.
• W3139093071 cites W2002406225 @default.
• W3139093071 cites W2008623163 @default.
• W3139093071 cites W2009845878 @default.
• W3139093071 cites W2015490435 @default.
• W3139093071 cites W2027349186 @default.
• W3139093071 cites W2027582676 @default.
• W3139093071 cites W2028124272 @default.
• W3139093071 cites W2031206337 @default.
• W3139093071 cites W2035734155 @default.
• W3139093071 cites W2035923088 @default.
• W3139093071 cites W2040016252 @default.
• W3139093071 cites W2042229295 @default.
• W3139093071 cites W2048468071 @default.
• W3139093071 cites W2051043829 @default.
• W3139093071 cites W2051255041 @default.
• W3139093071 cites W2058013649 @default.
• W3139093071 cites W2059753002 @default.
• W3139093071 cites W2063435136 @default.
• W3139093071 cites W2069089745 @default.
• W3139093071 cites W2073145057 @default.
• W3139093071 cites W2081351941 @default.
• W3139093071 cites W2085118586 @default.
• W3139093071 cites W2106508372 @default.
• W3139093071 cites W2108544092 @default.
• W3139093071 cites W2114995688 @default.
• W3139093071 cites W2116291866 @default.
• W3139093071 cites W2120233660 @default.
• W3139093071 cites W2126726647 @default.
• W3139093071 cites W2127080762 @default.
• W3139093071 cites W2127812709 @default.
• W3139093071 cites W2130832456 @default.
• W3139093071 cites W2133018490 @default.
• W3139093071 cites W2137567619 @default.
• W3139093071 cites W2142357559 @default.
• W3139093071 cites W2142583019 @default.
• W3139093071 cites W2146227335 @default.
• W3139093071 cites W2152549095 @default.
• W3139093071 cites W2160129587 @default.
• W3139093071 cites W2161449050 @default.
• W3139093071 cites W2163574914 @default.
• W3139093071 cites W2164360539 @default.
• W3139093071 cites W2169300456 @default.
• W3139093071 cites W2170398347 @default.
• W3139093071 cites W2172076789 @default.
• W3139093071 cites W2182293539 @default.
• W3139093071 cites W2236130432 @default.
• W3139093071 cites W2244273880 @default.
• W3139093071 cites W2401733806 @default.
• W3139093071 cites W2460218705 @default.
• W3139093071 cites W2559537906 @default.
• W3139093071 cites W2586162879 @default.
• W3139093071 cites W2594967879 @default.
• W3139093071 cites W2612805962 @default.
• W3139093071 cites W2621665063 @default.
• W3139093071 cites W2622063078 @default.
• W3139093071 cites W2765151185 @default.
• W3139093071 cites W2796271069 @default.
• W3139093071 cites W2802724103 @default.
• W3139093071 cites W2885323958 @default.
• W3139093071 cites W4313055163 @default.
• W3139093071 cites W54801374 @default.
• W3139093071 doi "https://doi.org/10.1016/j.imbio.2021.152088" @default.
• W3139093071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33838552" @default.

• next