FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3139104405> ?p ?o ?g. }

• W3139104405 endingPage "122671" @default.
• W3139104405 startingPage "122671" @default.
• W3139104405 abstract "Aloperine, a novel natural active alkaloid derived from Sophora alopecuroides L., has attracted much attention for its anti-inflammatory, antiviral, anti-tumor, anti-allergy and other pharmacological activities. In this study, we first established and validated an efficient and sensitive high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantification of aloperine in rat plasma. Cytisine was used as the internal standard (IS). The separation of aloperine and IS was conducted on a Phenomenex Luna Omega Polar C18 column (2.1 × 50 mm, 1.6 μm) with 0.3% (v/v) formic acid aqueous (containing 5 mM ammonium acetate) and 0.3% (v/v) formic acid acetonitrile using isocratic elution condition at a flow rate of 0.20 mL/min. Aloperine and IS were determined under the transitions of m/z 233.2 → 98.1 and m/z 191.2 → 148.2 (positive ionization mode), respectively. The calibration curve of aloperine was established in the range of 5 (LLOQ) to 2000 ng/mL (r2 = 0.994). The well validated method was full compliance with the bioanalytical method validation of FDA, and was applied to the pharmacokinetic study of aloperine in Sprague-Dawley rats after 50 mg/kg oral administration and 5 mg/kg intravenous injection. This study provides valuable references for the further study of Sophora alopecuroides L., especially for the drug development and clinical application of aloperine." @default.
• W3139104405 created "2021-03-29" @default.
• W3139104405 creator A5003577700 @default.
• W3139104405 creator A5003869008 @default.
• W3139104405 creator A5004145498 @default.
• W3139104405 creator A5052728154 @default.
• W3139104405 creator A5054879818 @default.
• W3139104405 creator A5073753623 @default.
• W3139104405 date "2021-05-01" @default.
• W3139104405 modified "2023-09-26" @default.
• W3139104405 title "Establishment of LC-MS/MS method for determination of aloperine in rat plasma and its application in preclinical pharmacokinetics" @default.
• W3139104405 cites W1602096681 @default.
• W3139104405 cites W1987588843 @default.
• W3139104405 cites W2041369350 @default.
• W3139104405 cites W2071455736 @default.
• W3139104405 cites W2088658742 @default.
• W3139104405 cites W2166144884 @default.
• W3139104405 cites W2239418106 @default.
• W3139104405 cites W2411268401 @default.
• W3139104405 cites W2559930389 @default.
• W3139104405 cites W2594426748 @default.
• W3139104405 cites W2762048810 @default.
• W3139104405 cites W2767798052 @default.
• W3139104405 cites W2791028904 @default.
• W3139104405 cites W2791092902 @default.
• W3139104405 cites W2791638217 @default.
• W3139104405 cites W2801470515 @default.
• W3139104405 cites W2886823489 @default.
• W3139104405 cites W2889912649 @default.
• W3139104405 cites W2914768619 @default.
• W3139104405 cites W2921694795 @default.
• W3139104405 cites W2971251358 @default.
• W3139104405 cites W2978766098 @default.
• W3139104405 cites W2984021626 @default.
• W3139104405 cites W2997334101 @default.
• W3139104405 cites W3007993575 @default.
• W3139104405 cites W3033430172 @default.
• W3139104405 cites W3205972787 @default.
• W3139104405 cites W4242912812 @default.
• W3139104405 doi "https://doi.org/10.1016/j.jchromb.2021.122671" @default.
• W3139104405 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33819795" @default.
• W3139104405 hasPublicationYear "2021" @default.
• W3139104405 type Work @default.
• W3139104405 sameAs 3139104405 @default.
• W3139104405 citedByCount "5" @default.
• W3139104405 countsByYear W31391044052022 @default.
• W3139104405 countsByYear W31391044052023 @default.
• W3139104405 crossrefType "journal-article" @default.
• W3139104405 hasAuthorship W3139104405A5003577700 @default.
• W3139104405 hasAuthorship W3139104405A5003869008 @default.
• W3139104405 hasAuthorship W3139104405A5004145498 @default.
• W3139104405 hasAuthorship W3139104405A5052728154 @default.
• W3139104405 hasAuthorship W3139104405A5054879818 @default.
• W3139104405 hasAuthorship W3139104405A5073753623 @default.
• W3139104405 hasConcept C112705442 @default.
• W3139104405 hasConcept C137535248 @default.
• W3139104405 hasConcept C162356407 @default.
• W3139104405 hasConcept C179998833 @default.
• W3139104405 hasConcept C185592680 @default.
• W3139104405 hasConcept C2777379063 @default.
• W3139104405 hasConcept C2780782300 @default.
• W3139104405 hasConcept C31827203 @default.
• W3139104405 hasConcept C43617362 @default.
• W3139104405 hasConcept C64489805 @default.
• W3139104405 hasConcept C71043704 @default.
• W3139104405 hasConcept C71924100 @default.
• W3139104405 hasConcept C98274493 @default.
• W3139104405 hasConceptScore W3139104405C112705442 @default.
• W3139104405 hasConceptScore W3139104405C137535248 @default.
• W3139104405 hasConceptScore W3139104405C162356407 @default.
• W3139104405 hasConceptScore W3139104405C179998833 @default.
• W3139104405 hasConceptScore W3139104405C185592680 @default.
• W3139104405 hasConceptScore W3139104405C2777379063 @default.
• W3139104405 hasConceptScore W3139104405C2780782300 @default.
• W3139104405 hasConceptScore W3139104405C31827203 @default.
• W3139104405 hasConceptScore W3139104405C43617362 @default.
• W3139104405 hasConceptScore W3139104405C64489805 @default.
• W3139104405 hasConceptScore W3139104405C71043704 @default.
• W3139104405 hasConceptScore W3139104405C71924100 @default.
• W3139104405 hasConceptScore W3139104405C98274493 @default.
• W3139104405 hasFunder F4320321885 @default.
• W3139104405 hasLocation W31391044051 @default.
• W3139104405 hasOpenAccess W3139104405 @default.
• W3139104405 hasPrimaryLocation W31391044051 @default.
• W3139104405 hasRelatedWork W1983305510 @default.
• W3139104405 hasRelatedWork W2008010175 @default.
• W3139104405 hasRelatedWork W2018795835 @default.
• W3139104405 hasRelatedWork W2058021281 @default.
• W3139104405 hasRelatedWork W2080814957 @default.
• W3139104405 hasRelatedWork W2082766191 @default.
• W3139104405 hasRelatedWork W2361819206 @default.
• W3139104405 hasRelatedWork W2625685112 @default.
• W3139104405 hasRelatedWork W2900172012 @default.
• W3139104405 hasRelatedWork W1973321026 @default.
• W3139104405 hasVolume "1173" @default.
• W3139104405 isParatext "false" @default.
• W3139104405 isRetracted "false" @default.
• W3139104405 magId "3139104405" @default.

• next