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- W3139157440 abstract "There are limited data about the molecular characteristics and response to diverse TKI of EGFR L747 position mutation in NSCLC patients. In this study, we aim to evaluate the molecular distribution and response to EGFR TKIs of EGFR L747 position mutations. Next-generation sequencing (NGS) tests were performed in 41369 lung cancer patients (Geneseeq). The distribution and co-occurring molecular characteristics of EGFR L747 mutations were analyzed. Five EGFR L747 mutated patients (three EGFR L747P and two EGFR L747S patients) were retrospectively collected to evaluate the clinical response to different EGFR TKIs from hospital. Through NGS analysis, 17084 patients (41.3%, 17084/41369) were confirmed EGFR-positive. EGFR L747 position mutations were identified in 68 patients (0.4%, 68/17084), including 44 EGFR L747P, 21 EGFR L747S and 3 EGFR L747V. Among EGFR L747 position mutated patients, individual EGFR mutation were detected in 23 patients (All EGFR L747P), and 45 cases were found to occur with other EGFR mutations, mostly EGFR L858R, EGFR 19del and G719X mutations. As for patients treated with EGFR TKIs, three EGFR L747P patients achieved partial response through afatinib treatment, and two EGFR L747S patient achieved progressive disease to icotinib treatment. EGFR L747 mutations account for 0.4% in EGFR-mutated NSCLC patients and EGFR L747P/S/V were common mutations identified. EGFR L747P might exert superior sensitivity to afatinib treatment and both EGFR L747P and L747S displayed poor response to first-generation EGFR TKI. Table 1. Clinical response to different EGFR TKIs in EGFR L747 mutated patients. PD, progressive disease; PR, partial response; SD, stable disease; PFS, progression free survival.Tabled 1patientsAgegenderMutationEGFR TKIsBest responsePFS149YMaleEGFR L747PGefitinib Afatinib ongoingPD PR0.9m 11.8m241YMaleEGFR L747PAfatinib ongoingPR7.3m347YFemaleEGFR L747P EGFR amplificationErlotinib/Radiation Osimertinib Afatinib ongoingSD SD PR6.2m 1.0m 5.5m456YMaleEGFR L747SIcotinibPD1.8m552YFemaleEGFR L747SIcotinibPD1.0m Open table in a new tab" @default.
- W3139157440 created "2021-03-29" @default.
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- W3139157440 date "2021-03-01" @default.
- W3139157440 modified "2023-09-23" @default.
- W3139157440 title "P76.40 Molecular Characteristics and Response to EGFR TKIs of EGFR L747 Position Mutation in Lung Cancer Patients." @default.
- W3139157440 doi "https://doi.org/10.1016/j.jtho.2021.01.1097" @default.
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