FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3139157921> ?p ?o ?g. }

• W3139157921 endingPage "112136" @default.
• W3139157921 startingPage "112136" @default.
• W3139157921 abstract "The combined toxicological assessment provides a realistic approach for hazard evaluation of chemical cocktails that co-existed in the environment. This review provides a holistic insight into the studies highlighting the mixture toxicity of the endocrine-disrupting chemicals (EDCs), especially focusing on the screening of biochemical pathways and other toxicogenetic endpoints. Reviewed literature showed that numerous multiplexed toxicogenomic techniques were applied to determine reproductive effects in vertebrates, but limited studies were found in non-mammalian species after mixture chemical exposure. Further, we found that the experimental design and concentration selection are the two important parameters in mixture toxicity studies that should be time- and cost-effective, highly precise, and environmentally relevant. A summary of EDC mixtures affecting the thyroid axis, estrogen axis, androgen axis, growth stress, and immune system via in vivo bioassays was also presented. It is interesting to mention that majority of estrogenic effects of the mixtures were sex-dependent, particularly observed in male fish as compared to female fish. Further, the androgen axis was perturbed with serious malformations in male rat testis (epididymal or gubernacular lesions, and deciduous spermatids). Also, transgenerational epigenetic effects were promoted in the F3 and F4 generations in the form of DNA methylation epimutations in sperm, increasing polycystic ovaries and reducing the offspring. Similarly, increased oxidative stress, high antioxidant enzymatic activities, disturbed estrous cycle, and decreased steroidogenesis were the commonly found effects after acute or chronic exposure to EDC mixtures. Importantly, the concentration addition (CA) and independent action (IA) models became more prevalent and suitable predictive models to unveil the prominence of synergistic estrogenic and anti-androgenic effects of chemical mixtures. More importantly, this review encompasses the research challenges and gaps in the existing knowledge and specific future research perspectives on combined toxicity." @default.
• W3139157921 created "2021-03-29" @default.
• W3139157921 creator A5026492595 @default.
• W3139157921 creator A5042938980 @default.
• W3139157921 creator A5057078099 @default.
• W3139157921 date "2021-06-01" @default.
• W3139157921 modified "2023-10-12" @default.
• W3139157921 title "Combined toxicity of endocrine-disrupting chemicals: A review" @default.
• W3139157921 cites W1031597514 @default.
• W3139157921 cites W1154753754 @default.
• W3139157921 cites W1838963582 @default.
• W3139157921 cites W1964209583 @default.
• W3139157921 cites W1964556068 @default.
• W3139157921 cites W1965544980 @default.
• W3139157921 cites W1969291923 @default.
• W3139157921 cites W1970121614 @default.
• W3139157921 cites W1970606355 @default.
• W3139157921 cites W1972963371 @default.
• W3139157921 cites W1974753926 @default.
• W3139157921 cites W1975084164 @default.
• W3139157921 cites W1976728854 @default.
• W3139157921 cites W1979289112 @default.
• W3139157921 cites W1983575650 @default.
• W3139157921 cites W1985956131 @default.
• W3139157921 cites W1986372611 @default.
• W3139157921 cites W1988348477 @default.
• W3139157921 cites W1990050054 @default.
• W3139157921 cites W1990148642 @default.
• W3139157921 cites W1993099117 @default.
• W3139157921 cites W2000961668 @default.
• W3139157921 cites W2001762283 @default.
• W3139157921 cites W2002058908 @default.
• W3139157921 cites W2002067669 @default.
• W3139157921 cites W2002724418 @default.
• W3139157921 cites W2009262506 @default.
• W3139157921 cites W2010782635 @default.
• W3139157921 cites W2012044884 @default.
• W3139157921 cites W2019850946 @default.
• W3139157921 cites W2023190287 @default.
• W3139157921 cites W2023589198 @default.
• W3139157921 cites W2024543159 @default.
• W3139157921 cites W2025969164 @default.
• W3139157921 cites W2030886815 @default.
• W3139157921 cites W2032271095 @default.
• W3139157921 cites W2035101277 @default.
• W3139157921 cites W2035689300 @default.
• W3139157921 cites W2038848727 @default.
• W3139157921 cites W2039206880 @default.
• W3139157921 cites W2039744318 @default.
• W3139157921 cites W2059239729 @default.
• W3139157921 cites W2061136308 @default.
• W3139157921 cites W2061706353 @default.
• W3139157921 cites W2065844900 @default.
• W3139157921 cites W2066389584 @default.
• W3139157921 cites W2068581356 @default.
• W3139157921 cites W2069441678 @default.
• W3139157921 cites W2069626422 @default.
• W3139157921 cites W2071430420 @default.
• W3139157921 cites W2074303411 @default.
• W3139157921 cites W2078871475 @default.
• W3139157921 cites W2084455775 @default.
• W3139157921 cites W2085155194 @default.
• W3139157921 cites W2085885436 @default.
• W3139157921 cites W2086461842 @default.
• W3139157921 cites W2087374366 @default.
• W3139157921 cites W2096479844 @default.
• W3139157921 cites W2096756074 @default.
• W3139157921 cites W2110634607 @default.
• W3139157921 cites W2121773244 @default.
• W3139157921 cites W2125454196 @default.
• W3139157921 cites W2140855177 @default.
• W3139157921 cites W2141558423 @default.
• W3139157921 cites W2145355485 @default.
• W3139157921 cites W2158957221 @default.
• W3139157921 cites W2165329755 @default.
• W3139157921 cites W2165700542 @default.
• W3139157921 cites W2272310968 @default.
• W3139157921 cites W2338379511 @default.
• W3139157921 cites W2413842318 @default.
• W3139157921 cites W2464700157 @default.
• W3139157921 cites W2474596148 @default.
• W3139157921 cites W2491639370 @default.
• W3139157921 cites W2564041407 @default.
• W3139157921 cites W2570768824 @default.
• W3139157921 cites W2578684539 @default.
• W3139157921 cites W2581337084 @default.
• W3139157921 cites W2609296770 @default.
• W3139157921 cites W2728340335 @default.
• W3139157921 cites W2746378596 @default.
• W3139157921 cites W2757380495 @default.
• W3139157921 cites W2767483900 @default.
• W3139157921 cites W2767534788 @default.
• W3139157921 cites W2769210277 @default.
• W3139157921 cites W2782595537 @default.
• W3139157921 cites W2790107799 @default.
• W3139157921 cites W2792469726 @default.
• W3139157921 cites W2792896688 @default.
• W3139157921 cites W2793338192 @default.

• next