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• W3139173885 abstract "Ion channels behave differently based on cellular location. Well established research characterizes the regulation of intracellular Ca2+ concentration by calcium channels, which is integral to Ca2+ dependent signaling cascades. Ca2+ dependent signaling cascades initiate cellular differentiation and apoptosis. Previous research suggests if calcium channel expression changes due to genetic mutation, the change in function may promote tumorigenesis and neoplastic cell proliferation. Altered calcium channels expression may also avert apoptosis, further contributing to cell proliferation and increased chemoresistance. Since calcium channels behave differently in neoplastic cells, scientists may develop calcium channel biomarker assays for diagnosis and prognosis. In this review, the expression changes per cancer cell type, utilizing calcium channels as biomarkers, and the main concerns are discussed." @default.
• W3139173885 created "2021-03-29" @default.
• W3139173885 creator A5032115640 @default.
• W3139173885 date "2020-01-01" @default.
• W3139173885 modified "2023-09-26" @default.
• W3139173885 title "Calcium Channels As Novel Biomarkers of Cancer" @default.
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• W3139173885 doi "https://doi.org/10.2139/ssrn.3573314" @default.
• W3139173885 hasPublicationYear "2020" @default.
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