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- W3139187735 abstract "In the beginning there was the simple autonomic system. Sympathetic nerves which released noradrenaline at the nerve endings and the parasympathetic which released acetyl choline at the nerve endings. These two systems were otherwise known as adrenergic and cholinergic nerves. Burnstock was the first to show that the innervation of the gut was much more complicated. Many more chemicals were release from autonomic nerves to make changes to gut function. Many of them involved chemicals known as Purines—these nerves were known as purinergic nerves. To make these things even more complicated, Furchote discovered that acetyl choline released another intermediary which finally caused an effect. Dissolved nitric oxide-NO was initially found in the endothelium of arteries but was also released as a short-acting muscle relaxing agent in the gut. The interstitial cells of Cahal (ICC) may also have a part to play in effecting a rapid neural reflex to cause sphincter contraction. Whatever the detail, the simple truth remained that acid entry into the duodenum caused sphincter contraction. This much was certain." @default.
- W3139187735 created "2021-03-29" @default.
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- W3139187735 date "2021-01-01" @default.
- W3139187735 modified "2023-10-14" @default.
- W3139187735 title "What makes the adult pyloric sphincter contract?" @default.
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- W3139187735 doi "https://doi.org/10.1016/b978-0-323-89776-1.00011-1" @default.
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