FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3139209589> ?p ?o ?g. }

• W3139209589 endingPage "1557" @default.
• W3139209589 startingPage "1547" @default.
• W3139209589 abstract "NUTM1 gene rearrangements were originally identified in NUT carcinoma. Recently, NUTM1 has been discovered to rearrange with a variety of gene partners in malignancies of diverse location and type. Only one NUTM1-rearranged tumor occurring in the colon has been reported. Herein we report five such tumors. The five tumors occurred in four females and one male, ranging from 38 to 67 years of age (median 51 years). The masses occurred in the colon (cecum, descending, sigmoid) and ileocecal valve region, measuring 2.5–20 cm in size (median 7 cm). Four patients had metastases at presentation (liver, n = 4; lymph nodes, n = 3). Histologically, the lesions arose in the submucosa, infiltrating into the mucosa and muscularis propria, and grew in fibrosarcoma-like fascicles and sheets of epithelioid or rhabdoid cells, with foci of hyalinized to vaguely osteoid-like matrix. The tumors were composed of relatively monomorphic, spindled to epithelioid cells with focal rhabdoid morphology, hyperchromatic nuclei, and small nucleoli. Mitotic activity was usually low (range 1–14/10 HPF; median 5/10 HPF); necrosis was present in two cases. Variable keratin expression and uniform nuclear NUT expression was present; KIT/DOG1 were negative and SMARCB1/SMARCA4 were retained. Next-generation sequencing identified MXD4-NUTM1 rearrangement in all cases (breakpoints: MXD4 exon 5, NUTM1 exons 2 or 3). Follow-up showed one of the four patients who presented with metastases to be dead of disease at 30 months; the other three patients were alive with metastatic disease. The final patient is disease-free, 5 months after diagnosis. NUTM1-rearranged colorectal sarcomas have characteristic morphologic, immunohistochemical, and molecular genetic features, suggesting that they represent a distinct entity within the family of NUTM1-rearranged neoplasia. A NUTM1-rearranged tumor should be considered for any difficult-to-classify submucosal spindle cell neoplasm of the gastrointestinal tract, in particular keratin-positive tumors showing an unusual combination of fibrosarcomatous, epithelioid to rhabdoid and hyalinized morphologies. Recognition of MXD4-NUTM1 rearranged sarcomas may be therapeutically important, even though best treatment is currently elusive/unknown." @default.
• W3139209589 created "2021-03-29" @default.
• W3139209589 creator A5009617807 @default.
• W3139209589 creator A5020223648 @default.
• W3139209589 creator A5033291031 @default.
• W3139209589 creator A5046301295 @default.
• W3139209589 creator A5047090871 @default.
• W3139209589 creator A5049215064 @default.
• W3139209589 creator A5053073600 @default.
• W3139209589 creator A5054413273 @default.
• W3139209589 creator A5075654183 @default.
• W3139209589 creator A5079599874 @default.
• W3139209589 creator A5079789936 @default.
• W3139209589 date "2021-08-01" @default.
• W3139209589 modified "2023-10-16" @default.
• W3139209589 title "NUTM1-rearranged colorectal sarcoma: a clinicopathologically and genetically distinctive malignant neoplasm with a poor prognosis" @default.
• W3139209589 cites W1572942885 @default.
• W3139209589 cites W2043876329 @default.
• W3139209589 cites W2054323652 @default.
• W3139209589 cites W2075280221 @default.
• W3139209589 cites W2077654461 @default.
• W3139209589 cites W2130552225 @default.
• W3139209589 cites W2164154570 @default.
• W3139209589 cites W2169944837 @default.
• W3139209589 cites W2233319314 @default.
• W3139209589 cites W2793717362 @default.
• W3139209589 cites W2800081119 @default.
• W3139209589 cites W2808625685 @default.
• W3139209589 cites W2892893971 @default.
• W3139209589 cites W2896381907 @default.
• W3139209589 cites W2898168488 @default.
• W3139209589 cites W2899627911 @default.
• W3139209589 cites W2904011139 @default.
• W3139209589 cites W2913295643 @default.
• W3139209589 cites W2943057983 @default.
• W3139209589 cites W2947453201 @default.
• W3139209589 cites W2964154314 @default.
• W3139209589 cites W2964496505 @default.
• W3139209589 cites W2972890732 @default.
• W3139209589 cites W2981604361 @default.
• W3139209589 cites W2985700496 @default.
• W3139209589 cites W3006380219 @default.
• W3139209589 cites W3022175316 @default.
• W3139209589 cites W3031629845 @default.
• W3139209589 cites W3047532435 @default.
• W3139209589 cites W3082737056 @default.
• W3139209589 cites W3083304361 @default.
• W3139209589 doi "https://doi.org/10.1038/s41379-021-00792-z" @default.
• W3139209589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33714983" @default.
• W3139209589 hasPublicationYear "2021" @default.
• W3139209589 type Work @default.
• W3139209589 sameAs 3139209589 @default.
• W3139209589 citedByCount "18" @default.
• W3139209589 countsByYear W31392095892021 @default.
• W3139209589 countsByYear W31392095892022 @default.
• W3139209589 countsByYear W31392095892023 @default.
• W3139209589 crossrefType "journal-article" @default.
• W3139209589 hasAuthorship W3139209589A5009617807 @default.
• W3139209589 hasAuthorship W3139209589A5020223648 @default.
• W3139209589 hasAuthorship W3139209589A5033291031 @default.
• W3139209589 hasAuthorship W3139209589A5046301295 @default.
• W3139209589 hasAuthorship W3139209589A5047090871 @default.
• W3139209589 hasAuthorship W3139209589A5049215064 @default.
• W3139209589 hasAuthorship W3139209589A5053073600 @default.
• W3139209589 hasAuthorship W3139209589A5054413273 @default.
• W3139209589 hasAuthorship W3139209589A5075654183 @default.
• W3139209589 hasAuthorship W3139209589A5079599874 @default.
• W3139209589 hasAuthorship W3139209589A5079789936 @default.
• W3139209589 hasBestOaLocation W31392095891 @default.
• W3139209589 hasConcept C118441373 @default.
• W3139209589 hasConcept C142724271 @default.
• W3139209589 hasConcept C204232928 @default.
• W3139209589 hasConcept C2778256501 @default.
• W3139209589 hasConcept C2779052585 @default.
• W3139209589 hasConcept C71924100 @default.
• W3139209589 hasConcept C86803240 @default.
• W3139209589 hasConceptScore W3139209589C118441373 @default.
• W3139209589 hasConceptScore W3139209589C142724271 @default.
• W3139209589 hasConceptScore W3139209589C204232928 @default.
• W3139209589 hasConceptScore W3139209589C2778256501 @default.
• W3139209589 hasConceptScore W3139209589C2779052585 @default.
• W3139209589 hasConceptScore W3139209589C71924100 @default.
• W3139209589 hasConceptScore W3139209589C86803240 @default.
• W3139209589 hasIssue "8" @default.
• W3139209589 hasLocation W31392095891 @default.
• W3139209589 hasLocation W31392095892 @default.
• W3139209589 hasOpenAccess W3139209589 @default.
• W3139209589 hasPrimaryLocation W31392095891 @default.
• W3139209589 hasRelatedWork W1973679753 @default.
• W3139209589 hasRelatedWork W1999047132 @default.
• W3139209589 hasRelatedWork W2026632382 @default.
• W3139209589 hasRelatedWork W2152089288 @default.
• W3139209589 hasRelatedWork W2261866633 @default.
• W3139209589 hasRelatedWork W2325166001 @default.
• W3139209589 hasRelatedWork W2394365381 @default.
• W3139209589 hasRelatedWork W3097156458 @default.
• W3139209589 hasRelatedWork W3140711681 @default.
• W3139209589 hasRelatedWork W3213764297 @default.

• next