Matches in SemOpenAlex for { <https://semopenalex.org/work/W3139224802> ?p ?o ?g. }
- W3139224802 abstract "Although coronavirus disease 2019 (COVID-19) causes cardiac dysfunction in up to 25% of patients, its pathogenesis remains unclear. Exposure of human induced pluripotent stem cell (iPSC)-derived heart cells to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) revealed productive infection and robust transcriptomic and morphological signatures of damage, particularly in cardiomyocytes. Transcriptomic disruption of structural genes corroborates adverse morphologic features, which included a distinct pattern of myofibrillar fragmentation and nuclear disruption. Human autopsy specimens from patients with COVID-19 reflected similar alterations, particularly sarcomeric fragmentation. These notable cytopathic features in cardiomyocytes provide insights into SARS-CoV-2-induced cardiac damage, offer a platform for discovery of potential therapeutics, and raise concerns about the long-term consequences of COVID-19 in asymptomatic and severe cases." @default.
- W3139224802 created "2021-03-29" @default.
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- W3139224802 date "2021-04-21" @default.
- W3139224802 modified "2023-10-18" @default.
- W3139224802 title "SARS-CoV-2 infection of human iPSC–derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19" @default.
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- W3139224802 doi "https://doi.org/10.1126/scitranslmed.abf7872" @default.