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• W3139274017 abstract "Astrocytes with intracellular accumulations of misfolded phosphorylated tau protein have been observed in advanced-stage chronic traumatic encephalopathy (CTE) and in other neurodegenerative conditions. There is a growing awareness that astrocytic tau inclusions are also relatively common in the brains of persons over 70 years of age-affecting approximately one-third of autopsied individuals. The pathologic hallmarks of aging-related tau astrogliopathy (ARTAG) include phosphorylated tau protein within thorn-shaped astrocytes (TSA) in subpial, subependymal, perivascular, and white matter regions, whereas granular-fuzzy astrocytes are often seen in gray matter. CTE and ARTAG share molecular and histopathologic characteristics, suggesting that trauma-related mechanism(s) may predispose to the development of tau astrogliopathy. There are presently few experimental systems to study the pathobiology of astrocytic-tau aggregation, but human studies have made recent progress. For example, leucotomy (also referred to as lobotomy) is associated with a localized ARTAG-like neuropathology decades after the surgical brain injury, suggesting that chronic brain injury of any type may predispose to later life ARTAG. To examine this idea in a different context, we report clinical and pathologic features of two middle-aged men who came to autopsy with large (> 6 cm in greatest dimension) arachnoid cysts that had physically displaced and injured the subjects' left temporal lobes through chronic mechanical stress. Despite the similarity of the size and location of the arachnoid cysts, these individuals had dissimilar neurologic outcomes and neuropathologic findings. We review the evidence for ARTAG in response to brain injury, and discuss how the location and molecular properties of astroglial tau inclusions might alter the physiology of resident astrocytes. These cases and literature review point toward possible mechanism(s) of tau aggregation in astrocytes in response to chronic brain trauma." @default.
• W3139274017 created "2021-03-29" @default.
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• W3139274017 date "2021-03-23" @default.
• W3139274017 modified "2023-10-14" @default.
• W3139274017 title "Space-occupying brain lesions, trauma-related tau astrogliopathy, and ARTAG: a report of two cases and a literature review" @default.
• W3139274017 cites W131578704 @default.
• W3139274017 cites W1482198038 @default.
• W3139274017 cites W1552434751 @default.
• W3139274017 cites W1832989852 @default.
• W3139274017 cites W1879183898 @default.
• W3139274017 cites W1902303720 @default.
• W3139274017 cites W1971125401 @default.
• W3139274017 cites W1993023011 @default.
• W3139274017 cites W2016927879 @default.
• W3139274017 cites W2018681635 @default.
• W3139274017 cites W2028535633 @default.
• W3139274017 cites W2031719597 @default.
• W3139274017 cites W2038823952 @default.
• W3139274017 cites W2041513277 @default.
• W3139274017 cites W2069498125 @default.
• W3139274017 cites W2076953252 @default.
• W3139274017 cites W2082429191 @default.
• W3139274017 cites W2105038182 @default.
• W3139274017 cites W2106729121 @default.
• W3139274017 cites W2117283190 @default.
• W3139274017 cites W2128228199 @default.
• W3139274017 cites W2140341262 @default.
• W3139274017 cites W2141679195 @default.
• W3139274017 cites W2142366168 @default.
• W3139274017 cites W2153121131 @default.
• W3139274017 cites W2159377066 @default.
• W3139274017 cites W2163234334 @default.
• W3139274017 cites W2171835565 @default.
• W3139274017 cites W2185034389 @default.
• W3139274017 cites W2195527239 @default.
• W3139274017 cites W2208088507 @default.
• W3139274017 cites W2217184110 @default.
• W3139274017 cites W2261145600 @default.
• W3139274017 cites W2516101459 @default.
• W3139274017 cites W2548378272 @default.
• W3139274017 cites W2552018811 @default.
• W3139274017 cites W2592627264 @default.
• W3139274017 cites W2606314986 @default.
• W3139274017 cites W2748477620 @default.
• W3139274017 cites W2766057155 @default.
• W3139274017 cites W2769140026 @default.
• W3139274017 cites W2791805346 @default.
• W3139274017 cites W2807741749 @default.
• W3139274017 cites W2808340672 @default.
• W3139274017 cites W2890680891 @default.
• W3139274017 cites W2892135048 @default.
• W3139274017 cites W2909158387 @default.
• W3139274017 cites W2913684613 @default.
• W3139274017 cites W2932013731 @default.
• W3139274017 cites W2932957054 @default.
• W3139274017 cites W2939877474 @default.
• W3139274017 cites W2943828894 @default.
• W3139274017 cites W2946938553 @default.
• W3139274017 cites W2952010976 @default.
• W3139274017 cites W2980169470 @default.
• W3139274017 cites W2980716100 @default.
• W3139274017 cites W2986586763 @default.
• W3139274017 cites W2991414673 @default.
• W3139274017 cites W2994914024 @default.
• W3139274017 cites W2998827051 @default.
• W3139274017 cites W2999370828 @default.
• W3139274017 cites W3001432200 @default.
• W3139274017 cites W3003275217 @default.
• W3139274017 cites W3015401334 @default.
• W3139274017 cites W3015511259 @default.
• W3139274017 cites W3017664168 @default.
• W3139274017 cites W3020538763 @default.
• W3139274017 cites W3034008742 @default.
• W3139274017 cites W3044691990 @default.
• W3139274017 cites W3045897262 @default.
• W3139274017 cites W3046035119 @default.
• W3139274017 cites W3083733923 @default.
• W3139274017 cites W3089028754 @default.
• W3139274017 cites W3089352106 @default.
• W3139274017 cites W3089407290 @default.
• W3139274017 cites W3093150127 @default.
• W3139274017 cites W3097079033 @default.
• W3139274017 cites W3108469472 @default.
• W3139274017 cites W3113110609 @default.
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• W3139274017 doi "https://doi.org/10.1186/s40478-021-01152-3" @default.
• W3139274017 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7986305" @default.
• W3139274017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33757579" @default.
• W3139274017 hasPublicationYear "2021" @default.
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