FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3139288294> ?p ?o ?g. }

• W3139288294 endingPage "101939" @default.
• W3139288294 startingPage "101939" @default.
• W3139288294 abstract "One of the underlying mechanisms that could link breast cancer and obesity is shifted redox homeostasis in the tumor microenvironment. To reveal the relationship between the malignant phenotype and obesity, we compared redox profiles of breast tumor and tumor-associated adipose tissue from premenopausal women: normal-weight with benign tumors, overweight/obese with benign tumors, normal-weight with malignant tumors, and overweight/obese with malignant tumors. Namely, we examined the protein expression of nuclear factor erythroid 2-related factor 2 (Nrf2), protein expression and activity of main antioxidant defense (AD) enzymes: copper, zinc- and manganese superoxide dismutase, catalase, and glutathione peroxidase, as well as the level of 4-hydroxy-2-nonenal (4-HNE) modified proteins. Higher protein expression and activity of AD enzymes were found in malignant tumor tissue than benign tumor tissue, irrespective of obesity. Nevertheless, malignant tumor tissue of overweight/obese women was characterized by higher protein expression of Nrf2 and weaker immunopositivity for 4-HNE modified proteins. In malignant tumor-associated adipose tissue, the redox profile was clearly related to obesity. Higher Nrf2 protein expression and higher AD enzyme levels were observed in normal-weight women, while stronger immunopositivity for 4-HNE modified proteins was found in overweight/obese women. The results suggest that the complex interplay between obesity and malignancy involves redox-sensitive pathways in breast tumor and tumor-associated adipose tissue." @default.
• W3139288294 created "2021-03-29" @default.
• W3139288294 creator A5022599724 @default.
• W3139288294 creator A5043429127 @default.
• W3139288294 creator A5047679776 @default.
• W3139288294 creator A5057338611 @default.
• W3139288294 creator A5061956319 @default.
• W3139288294 creator A5066531744 @default.
• W3139288294 creator A5071014185 @default.
• W3139288294 date "2021-05-01" @default.
• W3139288294 modified "2023-10-18" @default.
• W3139288294 title "Redox profile of breast tumor and associated adipose tissue in premenopausal women - Interplay between obesity and malignancy" @default.
• W3139288294 cites W1750690213 @default.
• W3139288294 cites W1972779889 @default.
• W3139288294 cites W1977949752 @default.
• W3139288294 cites W1983346636 @default.
• W3139288294 cites W1988622893 @default.
• W3139288294 cites W1989357594 @default.
• W3139288294 cites W1989509611 @default.
• W3139288294 cites W1993511165 @default.
• W3139288294 cites W1996971419 @default.
• W3139288294 cites W2008737341 @default.
• W3139288294 cites W2009399859 @default.
• W3139288294 cites W2020018742 @default.
• W3139288294 cites W2020582607 @default.
• W3139288294 cites W2025838009 @default.
• W3139288294 cites W2027412571 @default.
• W3139288294 cites W2027605252 @default.
• W3139288294 cites W2028282157 @default.
• W3139288294 cites W2030033321 @default.
• W3139288294 cites W2037737165 @default.
• W3139288294 cites W2048981098 @default.
• W3139288294 cites W2053047691 @default.
• W3139288294 cites W2057340727 @default.
• W3139288294 cites W2059699638 @default.
• W3139288294 cites W2064689563 @default.
• W3139288294 cites W2065736951 @default.
• W3139288294 cites W2070666438 @default.
• W3139288294 cites W2071687327 @default.
• W3139288294 cites W2081260625 @default.
• W3139288294 cites W2089210293 @default.
• W3139288294 cites W2090507503 @default.
• W3139288294 cites W2098175562 @default.
• W3139288294 cites W2114072360 @default.
• W3139288294 cites W2115226530 @default.
• W3139288294 cites W2124821727 @default.
• W3139288294 cites W2128012854 @default.
• W3139288294 cites W2133665471 @default.
• W3139288294 cites W2141603634 @default.
• W3139288294 cites W2148537305 @default.
• W3139288294 cites W2153383900 @default.
• W3139288294 cites W2159494912 @default.
• W3139288294 cites W2159905780 @default.
• W3139288294 cites W2164551609 @default.
• W3139288294 cites W2167154664 @default.
• W3139288294 cites W2167304097 @default.
• W3139288294 cites W2168034726 @default.
• W3139288294 cites W2168149223 @default.
• W3139288294 cites W2190836040 @default.
• W3139288294 cites W2229366053 @default.
• W3139288294 cites W2328008151 @default.
• W3139288294 cites W2398516887 @default.
• W3139288294 cites W2415945663 @default.
• W3139288294 cites W2465673666 @default.
• W3139288294 cites W2467354752 @default.
• W3139288294 cites W2541436531 @default.
• W3139288294 cites W2556968169 @default.
• W3139288294 cites W2573612572 @default.
• W3139288294 cites W2589120174 @default.
• W3139288294 cites W2597272587 @default.
• W3139288294 cites W2608631438 @default.
• W3139288294 cites W2616570004 @default.
• W3139288294 cites W2765421232 @default.
• W3139288294 cites W2787921404 @default.
• W3139288294 cites W2792558334 @default.
• W3139288294 cites W2792947498 @default.
• W3139288294 cites W2900887798 @default.
• W3139288294 cites W2909710577 @default.
• W3139288294 cites W2933115845 @default.
• W3139288294 cites W3111111721 @default.
• W3139288294 cites W3126898583 @default.
• W3139288294 cites W831177683 @default.
• W3139288294 doi "https://doi.org/10.1016/j.redox.2021.101939" @default.
• W3139288294 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8008245" @default.
• W3139288294 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33765617" @default.
• W3139288294 hasPublicationYear "2021" @default.
• W3139288294 type Work @default.
• W3139288294 sameAs 3139288294 @default.
• W3139288294 citedByCount "4" @default.
• W3139288294 countsByYear W31392882942021 @default.
• W3139288294 countsByYear W31392882942022 @default.
• W3139288294 countsByYear W31392882942023 @default.
• W3139288294 crossrefType "journal-article" @default.
• W3139288294 hasAuthorship W3139288294A5022599724 @default.
• W3139288294 hasAuthorship W3139288294A5043429127 @default.
• W3139288294 hasAuthorship W3139288294A5047679776 @default.
• W3139288294 hasAuthorship W3139288294A5057338611 @default.
• W3139288294 hasAuthorship W3139288294A5061956319 @default.

• next