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- W3139317535 abstract "Celastrol，源于根源Tripterygium wilfordi.，表明了对肥胖症的突出影响。在本研究中，使用代谢组科和转录组织研究了Celastrol在胆汁淤积中的作用。 Celastrol治疗显着缓解了由α-萘硫基异硫氰酸酯（Anit）和硫代乙酰胺（TaA）诱导的小鼠胆汁淤积肝损伤。发现Celastrol激活Sirtuin 1（SIRT1），增加法呢X受体（FXR）信号传导和抑制核因子-Kappa B和P53信号传导。 Celastrol在胆汁淤积肝损伤中的保护作用在CIRS中的CIRS CORS1抑制剂的共同施用中减少。此外，Celastrol对胆汁肝损伤的影响急剧下降Fxr-Null小鼠，表明SIRT1-FXR信号通路介导Celastrol的保护作用。这些观察结果表明了Celastrol在通过调节SIRT1和FXR来保护胆固性肝损伤的新颖作用。" @default.
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- W3139317535 date "2019-03-01" @default.
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- W3139317535 title "Celastrol通过调制SIRT1-FXR信号传导来保护胆汁淤积肝损伤* [S]" @default.
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