FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3139322170> ?p ?o ?g. }

• W3139322170 abstract "Anlotinib is an anti-angiogenetic multi-targeted tyrosine kinase inhibitor. This study aimed to evaluate the efficacy and safety of anlotinib in advanced non-small cell lung cancer (aNSCLC) in the real world.Patients with aNSCLC receiving anlotinib were enrolled in two cohorts (treatment naive and previously treated). The endpoints included progression-free survival (PFS), overall survival (OS) and anlotinib-related adverse events (ar-AEs).203 patients accrued in the study. In the treatment-naïve cohort (n = 80), the PFS was 7.4 (95% confidence interval [CI] 4.1-10.7) and OS was 10.8 (95% CI 5.8-15.8) months of monotherapy group (immature survival for combination group). In previously treated cohort (n = 123), the PFS was 8.0 months (95% CI 6.1-9.9) in the combination group and 4.3 months (95% CI 2.1-6.6) in the monotherapy group (hazard ratio [HR] 0.49; 95% CI 0.29-0.83; p = 0.007), respectively. The OS was 18.5 months (95% CI 10.5-26.6) in the combination group and 7.8 months (95% CI 7.1-8.4) in the monotherapy group (HR 0.38; 95% CI 0.22-0.66; p = 0.001), respectively. The ar-AEs of grade ≥ 3 in the monotherapy and the combination groups were hypertension (9.0 and 8.7%), fatigue (8.1 and 7.6%), hand-foot syndrome (8.1 and 6.5%), diarrhea (5.4 and 8.7%), proteinuria (5.4 and 5.4%), and mucositis oral (6.3 and 8.7%).In aNSCLC, anlotinib monotherapy has a promising efficacy in the first-line setting. It may be an option for those who are ineligible for chemotherapy; anlotinib combination therapy in a ≥ second-line setting showed manageable toxicities and encouraging efficacy, indicating a good application prospect.This study was retrospectively registered with ISRCTN Registry (ID ISRCTN35543977) on January 26th, 2021 and Chinese Clinical Trial Register (ChiCTR2000032265) on April 4th, 2020." @default.
• W3139322170 created "2021-03-29" @default.
• W3139322170 creator A5010776860 @default.
• W3139322170 creator A5042380657 @default.
• W3139322170 creator A5047017832 @default.
• W3139322170 creator A5075130252 @default.
• W3139322170 creator A5084091087 @default.
• W3139322170 creator A5089732639 @default.
• W3139322170 date "2021-08-06" @default.
• W3139322170 modified "2023-09-26" @default.
• W3139322170 title "The real-world efficacy and safety of anlotinib in advanced non-small cell lung cancer" @default.
• W3139322170 cites W1769347004 @default.
• W3139322170 cites W1861063348 @default.
• W3139322170 cites W1930662350 @default.
• W3139322170 cites W1970784908 @default.
• W3139322170 cites W1975814972 @default.
• W3139322170 cites W1978111504 @default.
• W3139322170 cites W1983576003 @default.
• W3139322170 cites W1986128216 @default.
• W3139322170 cites W2019607817 @default.
• W3139322170 cites W2022030290 @default.
• W3139322170 cites W2031597668 @default.
• W3139322170 cites W2035752036 @default.
• W3139322170 cites W2037139573 @default.
• W3139322170 cites W2038316782 @default.
• W3139322170 cites W2041962318 @default.
• W3139322170 cites W2085188665 @default.
• W3139322170 cites W2089900585 @default.
• W3139322170 cites W2091553939 @default.
• W3139322170 cites W2099725888 @default.
• W3139322170 cites W2102590541 @default.
• W3139322170 cites W2104104624 @default.
• W3139322170 cites W2105464202 @default.
• W3139322170 cites W2109240520 @default.
• W3139322170 cites W2112524831 @default.
• W3139322170 cites W2115078104 @default.
• W3139322170 cites W2120009106 @default.
• W3139322170 cites W2123584388 @default.
• W3139322170 cites W2124464299 @default.
• W3139322170 cites W2127405377 @default.
• W3139322170 cites W2128002599 @default.
• W3139322170 cites W2135140316 @default.
• W3139322170 cites W2140103603 @default.
• W3139322170 cites W2140980839 @default.
• W3139322170 cites W2144660856 @default.
• W3139322170 cites W2145835533 @default.
• W3139322170 cites W2148367564 @default.
• W3139322170 cites W2148911877 @default.
• W3139322170 cites W2152140953 @default.
• W3139322170 cites W2152376701 @default.
• W3139322170 cites W2159370421 @default.
• W3139322170 cites W2160373161 @default.
• W3139322170 cites W2166084034 @default.
• W3139322170 cites W2170024262 @default.
• W3139322170 cites W2170030318 @default.
• W3139322170 cites W2170825454 @default.
• W3139322170 cites W2206185841 @default.
• W3139322170 cites W2218718059 @default.
• W3139322170 cites W2304373741 @default.
• W3139322170 cites W2511951051 @default.
• W3139322170 cites W2528424364 @default.
• W3139322170 cites W2544627141 @default.
• W3139322170 cites W2766812598 @default.
• W3139322170 cites W2782736026 @default.
• W3139322170 cites W2791043965 @default.
• W3139322170 cites W2791667474 @default.
• W3139322170 cites W2793605704 @default.
• W3139322170 cites W2796582438 @default.
• W3139322170 cites W2808479470 @default.
• W3139322170 cites W2885503610 @default.
• W3139322170 cites W2888529999 @default.
• W3139322170 cites W2891909134 @default.
• W3139322170 cites W2892220650 @default.
• W3139322170 cites W2894281218 @default.
• W3139322170 cites W2898107810 @default.
• W3139322170 cites W2911188335 @default.
• W3139322170 cites W2917630208 @default.
• W3139322170 cites W2937223370 @default.
• W3139322170 cites W2945912081 @default.
• W3139322170 cites W2951071083 @default.
• W3139322170 cites W2964474004 @default.
• W3139322170 cites W2969136866 @default.
• W3139322170 cites W2972306175 @default.
• W3139322170 cites W2977587593 @default.
• W3139322170 cites W2978677918 @default.
• W3139322170 cites W2981557251 @default.
• W3139322170 cites W2984723030 @default.
• W3139322170 cites W2990041408 @default.
• W3139322170 cites W3009099064 @default.
• W3139322170 cites W3025992067 @default.
• W3139322170 cites W3029089429 @default.
• W3139322170 cites W3030699384 @default.
• W3139322170 cites W3030891775 @default.
• W3139322170 cites W3107877953 @default.
• W3139322170 cites W3126928179 @default.
• W3139322170 cites W3152809041 @default.
• W3139322170 cites W3183409909 @default.
• W3139322170 cites W4210394199 @default.
• W3139322170 doi "https://doi.org/10.1007/s00432-021-03752-x" @default.
• W3139322170 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8343360" @default.

• next