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- W3139328848 endingPage "512" @default.
- W3139328848 startingPage "494" @default.
- W3139328848 abstract "Gene therapy can be used to restore cell function in monogenic disorders or to endow cells with new capabilities, such as improved killing of cancer cells, expression of suicide genes for controlled elimination of cell populations, or protection against chemotherapy or viral infection. While gene therapies were originally most often used to treat monogenic diseases and to improve hematopoietic stem cell transplantation outcome, the advent of genetically modified immune cell therapies, such as chimeric antigen receptor modified T cells, has contributed to the increased numbers of patients treated with gene and cell therapies. The advancement of gene therapy with integrating retroviral vectors continues to depend upon world-wide efforts. As the topic of this special issue is Spotlight on Germany, the goal of this review is to provide an overview of contributions to this field made by German clinical and research institutions. Research groups in Germany made, and continue to make, important contributions to the development of gene therapy, including design of vectors and transduction protocols for improved cell modification, methods to assess gene therapy vector efficacy and safety (e.g., clonal imbalance, insertion sites), as well as in the design and conduction of clinical gene therapy trials." @default.
- W3139328848 created "2021-03-29" @default.
- W3139328848 creator A5011083669 @default.
- W3139328848 creator A5052933885 @default.
- W3139328848 creator A5054362291 @default.
- W3139328848 creator A5069929247 @default.
- W3139328848 creator A5091674525 @default.
- W3139328848 date "2021-03-22" @default.
- W3139328848 modified "2023-09-24" @default.
- W3139328848 title "Retroviral gene therapy in Germany with a view on previous experience and future perspectives" @default.
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