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• W3139331572 abstract "Zinc is known for anti-inflammatory and antioxidant roles. In this meta-analysis, we aim to evaluate the impact of zinc supplementation on inflammatory markers, acute-phase reactants, and serum zinc level during inflammatory and infectious diseases. PubMed, Scopus, and Web of Science databases were screened systematically with the terms “zinc supplementation” AND “CRP” OR “IL-1β” OR “IL-2” OR “IL-6” OR “IL-10” OR “IL-12” OR “TNF-α” OR “TGF-β” OR “IFN-γ” OR “WBC (clinical trial)” OR “macrophage (clinical trial)” OR “lymphocyte (clinical trial)” OR “neutrophil (clinical trial)” OR “virus (clinical trial)” OR “antiviral (clinical trial)” for all databases. A total of 2,258 publications were screened, and 73 articles had suitable data for the meta-analysis. Serum zinc level was significantly higher in supplementation group compared with controls [P = 0.0006, mean difference: 11.35 (4.84, 17.87)] (n = 37). Zinc supplementation downregulates acute-phase reactants, especially serum C-reactive protein (CRP) in adults [P < 0.00001, mean difference: −0.75 (−0.98, −0.52)] (n = 22) and pregnant women [FEM P < 0.00001, mean difference: −1.77 (−2.53, −1.00)] (n = 3) but not in children [REM P = 0.10, mean difference: −0.85 (−1.86, 0.17)] (n = 3). In subgroups analysis of chronic inflammatory diseases, serum CRP [REM P < 0.00001, mean difference: −0.57 (−0.76, −0.38)] were significantly lower in zinc-supplemented patients compared with no intervention group. Zinc supplementation (mg/day) correlated with serum interferon-gamma (IFN-γ) level (P = 0.018, r = 1,000). In the nonsupplemented group, serum zinc correlated with serum interleukin-6 (IL-6) level (P = 0.041, r = −0.829) and serum tumor necrosis factor alpha (TNF-α) level (P = 0.063, r = 0.730). Zinc intake correlated with serum zinc (P = 0.0428, r = 0.5115) and TNF-α (P = 0.0043, r = −0.9461). This meta-analysis shows that zinc supplementation improves CRP levels in adults and pregnant women. It might have modulatory effects on cytokine secretions and blood cells in inflammatory and infectious diseases. For the first time, we investigated the effects of zinc supplementation on inflammatory cytokine." @default.
• W3139331572 created "2021-03-29" @default.
• W3139331572 creator A5027807436 @default.
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• W3139331572 date "2021-03-01" @default.
• W3139331572 modified "2023-10-13" @default.
• W3139331572 title "The Effects of Zinc Supplementation on C-Reactive Protein and Inflammatory Cytokines: A Meta-Analysis and Systematical Review" @default.
• W3139331572 cites W1695691641 @default.
• W3139331572 cites W1814728608 @default.
• W3139331572 cites W187320919 @default.
• W3139331572 cites W1893906380 @default.
• W3139331572 cites W1925247835 @default.
• W3139331572 cites W1937049342 @default.
• W3139331572 cites W1971486155 @default.
• W3139331572 cites W1973569147 @default.
• W3139331572 cites W1974608832 @default.
• W3139331572 cites W1988237598 @default.
• W3139331572 cites W1991199071 @default.
• W3139331572 cites W1994060781 @default.
• W3139331572 cites W1996949867 @default.
• W3139331572 cites W1997850644 @default.
• W3139331572 cites W1998269518 @default.
• W3139331572 cites W1999424803 @default.
• W3139331572 cites W2003634240 @default.
• W3139331572 cites W2006589559 @default.
• W3139331572 cites W2012505692 @default.
• W3139331572 cites W2020344588 @default.
• W3139331572 cites W2023867262 @default.
• W3139331572 cites W2024571132 @default.
• W3139331572 cites W2032646623 @default.
• W3139331572 cites W2033822465 @default.
• W3139331572 cites W2035152237 @default.
• W3139331572 cites W2035805509 @default.
• W3139331572 cites W2037012613 @default.
• W3139331572 cites W2039034879 @default.
• W3139331572 cites W2040343050 @default.
• W3139331572 cites W2041027571 @default.
• W3139331572 cites W2042256294 @default.
• W3139331572 cites W2042865353 @default.
• W3139331572 cites W2058465738 @default.
• W3139331572 cites W2063353581 @default.
• W3139331572 cites W2063801972 @default.
• W3139331572 cites W2067927272 @default.
• W3139331572 cites W2069247917 @default.
• W3139331572 cites W2074122095 @default.
• W3139331572 cites W2077894812 @default.
• W3139331572 cites W2078331244 @default.
• W3139331572 cites W2083295260 @default.
• W3139331572 cites W2088298818 @default.
• W3139331572 cites W2088711804 @default.
• W3139331572 cites W2090380198 @default.
• W3139331572 cites W2095926729 @default.
• W3139331572 cites W2101062326 @default.
• W3139331572 cites W2109646632 @default.
• W3139331572 cites W2112130698 @default.
• W3139331572 cites W2115894981 @default.
• W3139331572 cites W2116969763 @default.
• W3139331572 cites W2125435699 @default.
• W3139331572 cites W2133124716 @default.
• W3139331572 cites W2155136631 @default.
• W3139331572 cites W2155495081 @default.
• W3139331572 cites W2156517251 @default.
• W3139331572 cites W2175283437 @default.
• W3139331572 cites W2230522203 @default.
• W3139331572 cites W2241884422 @default.
• W3139331572 cites W2252695849 @default.
• W3139331572 cites W2289203809 @default.
• W3139331572 cites W2291746563 @default.
• W3139331572 cites W2299926066 @default.
• W3139331572 cites W2325605248 @default.
• W3139331572 cites W2544381418 @default.
• W3139331572 cites W2611237833 @default.
• W3139331572 cites W2766600652 @default.
• W3139331572 cites W2767898738 @default.
• W3139331572 cites W2792096864 @default.
• W3139331572 cites W2792297320 @default.
• W3139331572 cites W2794227570 @default.
• W3139331572 cites W2801763182 @default.
• W3139331572 cites W2802834969 @default.
• W3139331572 cites W2809059905 @default.
• W3139331572 cites W2833585247 @default.
• W3139331572 cites W2969307346 @default.
• W3139331572 cites W2972743302 @default.
• W3139331572 cites W2991002877 @default.
• W3139331572 cites W3000246163 @default.
• W3139331572 cites W3004376866 @default.
• W3139331572 cites W3032120886 @default.
• W3139331572 cites W4243186624 @default.
• W3139331572 doi "https://doi.org/10.1089/jir.2020.0209" @default.
• W3139331572 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33750215" @default.
• W3139331572 hasPublicationYear "2021" @default.
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