Matches in SemOpenAlex for { <https://semopenalex.org/work/W3139332184> ?p ?o ?g. }
- W3139332184 endingPage "2571" @default.
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- W3139332184 abstract "Natural enzymes are efficient and versatile biocatalysts but suffer in their environmental tolerance and catalytic stability. As artificial enzymes, nanozymes can improve the catalytic stability, but it is still a challenge to achieve high catalytic activity. Here, we employed atomic engineering to build the artificial enzyme named Au24Ag1 clusterzyme that hosts an ultrahigh catalytic activity as well as strong physiological stability via atom manipulation. The designed Au24Ag1 clusterzyme activates the Ag–S active site via lattice expansion in the oligomer atom layer, showing an antioxidant property 72 times higher than that of natural antioxidant Trolox. Enzyme-mimicked studies find that Au24Ag1 clusterzyme exhibits high catalase-like (CAT-like) and glutathione peroxidase-like (GPx-like) activity with a maximum reaction rate of 68.9 and 17.8 μM/min, respectively. Meanwhile, the unique catalytic landscape exhibits distinctive reactions against inflammation by inhibiting the cytokines at an early stage in the brain. Atomic engineering of clusterzymes provides a powerful and attractive platform with satisfactory atomic dispersion for tailoring biocatalysts freely at the atomic level." @default.
- W3139332184 created "2021-03-29" @default.
- W3139332184 creator A5003642180 @default.
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- W3139332184 creator A5090510290 @default.
- W3139332184 date "2021-03-15" @default.
- W3139332184 modified "2023-10-17" @default.
- W3139332184 title "Atomic Engineering of Clusterzyme for Relieving Acute Neuroinflammation through Lattice Expansion" @default.
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