FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3139375672> ?p ?o ?g. }

• W3139375672 endingPage "3253" @default.
• W3139375672 startingPage "3253" @default.
• W3139375672 abstract "The world is on the verge of a major antibiotic crisis as the emergence of resistant bacteria is increasing, and very few novel molecules have been discovered since the 1960s. In this context, scientists have been exploring alternatives to conventional antibiotics, such as ribosomally synthesized and post-translationally modified peptides (RiPPs). Interestingly, the highly potent in vitro antibacterial activity and safety of ruminococcin C1, a recently discovered RiPP belonging to the sactipeptide subclass, has been demonstrated. The present results show that ruminococcin C1 is efficient at curing infection and at protecting challenged mice from Clostridium perfringens with a lower dose than the conventional antibiotic vancomycin. Moreover, antimicrobial peptide (AMP) is also effective against this pathogen in the complex microbial community of the gut environment, with a selective impact on a few bacterial genera, while maintaining a global homeostasis of the microbiome. In addition, ruminococcin C1 exhibits other biological activities that could be beneficial for human health, as well as other fields of applications. Overall, this study, by using an in vivo infection approach, confirms the antimicrobial clinical potential and highlights the multiple functional properties of ruminococcin C1, thus extending its therapeutic interest." @default.
• W3139375672 created "2021-03-29" @default.
• W3139375672 creator A5000871013 @default.
• W3139375672 creator A5003252858 @default.
• W3139375672 creator A5007874903 @default.
• W3139375672 creator A5011013386 @default.
• W3139375672 creator A5011391703 @default.
• W3139375672 creator A5025539418 @default.
• W3139375672 creator A5026037151 @default.
• W3139375672 creator A5030145419 @default.
• W3139375672 creator A5038626948 @default.
• W3139375672 creator A5043236875 @default.
• W3139375672 creator A5053620734 @default.
• W3139375672 creator A5055835369 @default.
• W3139375672 creator A5056198586 @default.
• W3139375672 creator A5065473864 @default.
• W3139375672 creator A5074202349 @default.
• W3139375672 creator A5076426241 @default.
• W3139375672 creator A5079028152 @default.
• W3139375672 creator A5080909081 @default.
• W3139375672 creator A5085149717 @default.
• W3139375672 date "2021-03-23" @default.
• W3139375672 modified "2023-10-18" @default.
• W3139375672 title "The Multifunctional Sactipeptide Ruminococcin C1 Displays Potent Antibacterial Activity In Vivo as Well as Other Beneficial Properties for Human Health" @default.
• W3139375672 cites W1604649731 @default.
• W3139375672 cites W1985189826 @default.
• W3139375672 cites W1990363562 @default.
• W3139375672 cites W2003652053 @default.
• W3139375672 cites W2008035557 @default.
• W3139375672 cites W2015542817 @default.
• W3139375672 cites W2016256427 @default.
• W3139375672 cites W2016272185 @default.
• W3139375672 cites W2035533154 @default.
• W3139375672 cites W2056400335 @default.
• W3139375672 cites W2057439652 @default.
• W3139375672 cites W2069812362 @default.
• W3139375672 cites W2079228339 @default.
• W3139375672 cites W2091426331 @default.
• W3139375672 cites W2103739116 @default.
• W3139375672 cites W2106351298 @default.
• W3139375672 cites W2107054191 @default.
• W3139375672 cites W2112738213 @default.
• W3139375672 cites W2115717127 @default.
• W3139375672 cites W2116279935 @default.
• W3139375672 cites W2136500114 @default.
• W3139375672 cites W2146401071 @default.
• W3139375672 cites W2162854463 @default.
• W3139375672 cites W2165924947 @default.
• W3139375672 cites W2229987747 @default.
• W3139375672 cites W2516886587 @default.
• W3139375672 cites W2529409893 @default.
• W3139375672 cites W2574749842 @default.
• W3139375672 cites W2575270489 @default.
• W3139375672 cites W2735527928 @default.
• W3139375672 cites W2750482881 @default.
• W3139375672 cites W2755612908 @default.
• W3139375672 cites W2765688972 @default.
• W3139375672 cites W2791827609 @default.
• W3139375672 cites W2793072766 @default.
• W3139375672 cites W2798143892 @default.
• W3139375672 cites W2804026753 @default.
• W3139375672 cites W2897109701 @default.
• W3139375672 cites W2912354751 @default.
• W3139375672 cites W2940213449 @default.
• W3139375672 cites W2942254658 @default.
• W3139375672 cites W2956038485 @default.
• W3139375672 cites W2959946736 @default.
• W3139375672 cites W2960142415 @default.
• W3139375672 cites W2968634496 @default.
• W3139375672 cites W2975466304 @default.
• W3139375672 cites W2977848076 @default.
• W3139375672 cites W2991550463 @default.
• W3139375672 cites W2996508375 @default.
• W3139375672 cites W3012943203 @default.
• W3139375672 cites W3044043637 @default.
• W3139375672 doi "https://doi.org/10.3390/ijms22063253" @default.
• W3139375672 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8005207" @default.
• W3139375672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33806791" @default.
• W3139375672 hasPublicationYear "2021" @default.
• W3139375672 type Work @default.
• W3139375672 sameAs 3139375672 @default.
• W3139375672 citedByCount "11" @default.
• W3139375672 countsByYear W31393756722022 @default.
• W3139375672 countsByYear W31393756722023 @default.
• W3139375672 crossrefType "journal-article" @default.
• W3139375672 hasAuthorship W3139375672A5000871013 @default.
• W3139375672 hasAuthorship W3139375672A5003252858 @default.
• W3139375672 hasAuthorship W3139375672A5007874903 @default.
• W3139375672 hasAuthorship W3139375672A5011013386 @default.
• W3139375672 hasAuthorship W3139375672A5011391703 @default.
• W3139375672 hasAuthorship W3139375672A5025539418 @default.
• W3139375672 hasAuthorship W3139375672A5026037151 @default.
• W3139375672 hasAuthorship W3139375672A5030145419 @default.
• W3139375672 hasAuthorship W3139375672A5038626948 @default.
• W3139375672 hasAuthorship W3139375672A5043236875 @default.
• W3139375672 hasAuthorship W3139375672A5053620734 @default.
• W3139375672 hasAuthorship W3139375672A5055835369 @default.
• W3139375672 hasAuthorship W3139375672A5056198586 @default.

• next