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- W3139438889 abstract "Hyperpolarized fumarate is a promising biosensor for carbon-13 magnetic resonance metabolic imaging. Such molecular imaging applications require nuclear hyperpolarization to attain sufficient signal strength. Dissolution dynamic nuclear polarization is the current state-of-the-art methodology for hyperpolarizing fumarate, but this is expensive and relatively slow. Alternatively, this important biomolecule can be hyperpolarized in a cheap and convenient manner using parahydrogen-induced polarization. However, this process requires a chemical reaction, and the resulting solutions are contaminated with the catalyst, unreacted reagents, and reaction side-product molecules, and are hence unsuitable for use in vivo. In this work we show that the hyperpolarized fumarate can be purified from these contaminants by acid precipitation as a pure solid, and later redissolved to a desired concentration in a clean aqueous solvent. Significant advances in the reaction conditions and reactor equipment allow for formation of hyperpolarized fumarate at 13C polarization levels of 30-45%." @default.
- W3139438889 created "2021-03-29" @default.
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- W3139438889 date "2021-03-22" @default.
- W3139438889 modified "2023-10-17" @default.
- W3139438889 title "Rapid hyperpolarization and purification of the metabolite fumarate in aqueous solution" @default.
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- W3139438889 doi "https://doi.org/10.1073/pnas.2025383118" @default.
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