Matches in SemOpenAlex for { <https://semopenalex.org/work/W3139453677> ?p ?o ?g. }
- W3139453677 endingPage "180" @default.
- W3139453677 startingPage "171" @default.
- W3139453677 abstract "Few patients with pancreatic adenocarcinoma (PAC) are eligible for surgery. Patients with early relapse have a poor prognosis and might be better candidates for a medical approach. Clinical and pathological parameters only partially predict recurrence and are only obtained after surgery. PAC subtypes based on gene expression were proposed, and we assessed if they could predict the risk and type of recurrence independently of clinicopathological parameters.Patients with curative-intent surgery for PAC without pretreatment were selected and divided into two independent cohorts defined as discovery (n = 381) and validation (n = 149) cohorts. Transcriptomic analyses were performed on formalin-fixed paraffin-embedded surgical samples to characterise tumour and stroma compartments using previously defined signatures. We associated molecular and clinicopathological characteristics with general, distant, and local recurrences using Cox regression analyses.We found that tumour biology predicted distant recurrence contrary to local recurrence, which was directly related to resection margin status. Pure basal-like and stroma-activated subtypes were strongly associated with distant recurrence, independently of clinicopathological factors (hazard ratios [HRs] = 5.85, p < 0.001 and HR = 1.75, p = 0.007, respectively). By dissecting tumoural and stromal compartments, we demonstrated that the basal-like tumour component positively correlated with distant recurrence in both cohorts (HR = 1.45, p < 0.001 and HR = 1.90, p < 0.001), whereas the inactive structural stroma component was protective against distant recurrence (HR = 0.68, p < 0.001 and HR = 0.72, p < 0.001).In addition to suggesting a different mechanism for local and distant relapse (incomplete resection and high metastatic potential, respectively), our results show the potency of molecular phenotype to predict patient outcome regarding distant recurrences." @default.
- W3139453677 created "2021-03-29" @default.
- W3139453677 creator A5006469032 @default.
- W3139453677 creator A5010902289 @default.
- W3139453677 creator A5023046965 @default.
- W3139453677 creator A5030107635 @default.
- W3139453677 creator A5035154674 @default.
- W3139453677 creator A5046106054 @default.
- W3139453677 creator A5050225498 @default.
- W3139453677 creator A5060346666 @default.
- W3139453677 creator A5061710022 @default.
- W3139453677 creator A5067073528 @default.
- W3139453677 creator A5070179654 @default.
- W3139453677 date "2021-05-01" @default.
- W3139453677 modified "2023-10-18" @default.
- W3139453677 title "Tumour and stroma RNA signatures predict more accurately distant recurrence than clinicopathological factors in resected pancreatic adenocarcinoma" @default.
- W3139453677 cites W2012503933 @default.
- W3139453677 cites W2138582833 @default.
- W3139453677 cites W2166022333 @default.
- W3139453677 cites W2317459595 @default.
- W3139453677 cites W2346921980 @default.
- W3139453677 cites W2394986081 @default.
- W3139453677 cites W2408868144 @default.
- W3139453677 cites W2416383077 @default.
- W3139453677 cites W2461298495 @default.
- W3139453677 cites W2506941105 @default.
- W3139453677 cites W2756017607 @default.
- W3139453677 cites W2770835903 @default.
- W3139453677 cites W2780727948 @default.
- W3139453677 cites W2889433609 @default.
- W3139453677 cites W2911188335 @default.
- W3139453677 cites W2943426452 @default.
- W3139453677 cites W2944271519 @default.
- W3139453677 cites W2948357501 @default.
- W3139453677 cites W2964289988 @default.
- W3139453677 cites W2966033121 @default.
- W3139453677 cites W2966064164 @default.
- W3139453677 cites W2988748484 @default.
- W3139453677 cites W2991084017 @default.
- W3139453677 cites W2999027176 @default.
- W3139453677 cites W3011562658 @default.
- W3139453677 cites W3039702151 @default.
- W3139453677 cites W3049239269 @default.
- W3139453677 cites W3091923748 @default.
- W3139453677 cites W3107567844 @default.
- W3139453677 cites W4254403825 @default.
- W3139453677 cites W995051720 @default.
- W3139453677 doi "https://doi.org/10.1016/j.ejca.2021.01.042" @default.
- W3139453677 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33743485" @default.
- W3139453677 hasPublicationYear "2021" @default.
- W3139453677 type Work @default.
- W3139453677 sameAs 3139453677 @default.
- W3139453677 citedByCount "6" @default.
- W3139453677 countsByYear W31394536772021 @default.
- W3139453677 countsByYear W31394536772022 @default.
- W3139453677 countsByYear W31394536772023 @default.
- W3139453677 crossrefType "journal-article" @default.
- W3139453677 hasAuthorship W3139453677A5006469032 @default.
- W3139453677 hasAuthorship W3139453677A5010902289 @default.
- W3139453677 hasAuthorship W3139453677A5023046965 @default.
- W3139453677 hasAuthorship W3139453677A5030107635 @default.
- W3139453677 hasAuthorship W3139453677A5035154674 @default.
- W3139453677 hasAuthorship W3139453677A5046106054 @default.
- W3139453677 hasAuthorship W3139453677A5050225498 @default.
- W3139453677 hasAuthorship W3139453677A5060346666 @default.
- W3139453677 hasAuthorship W3139453677A5061710022 @default.
- W3139453677 hasAuthorship W3139453677A5067073528 @default.
- W3139453677 hasAuthorship W3139453677A5070179654 @default.
- W3139453677 hasConcept C121608353 @default.
- W3139453677 hasConcept C126322002 @default.
- W3139453677 hasConcept C142724271 @default.
- W3139453677 hasConcept C143998085 @default.
- W3139453677 hasConcept C16930146 @default.
- W3139453677 hasConcept C204232928 @default.
- W3139453677 hasConcept C207103383 @default.
- W3139453677 hasConcept C207886595 @default.
- W3139453677 hasConcept C2778024521 @default.
- W3139453677 hasConcept C2779306644 @default.
- W3139453677 hasConcept C2781182431 @default.
- W3139453677 hasConcept C44249647 @default.
- W3139453677 hasConcept C50382708 @default.
- W3139453677 hasConcept C52124034 @default.
- W3139453677 hasConcept C71924100 @default.
- W3139453677 hasConcept C90924648 @default.
- W3139453677 hasConceptScore W3139453677C121608353 @default.
- W3139453677 hasConceptScore W3139453677C126322002 @default.
- W3139453677 hasConceptScore W3139453677C142724271 @default.
- W3139453677 hasConceptScore W3139453677C143998085 @default.
- W3139453677 hasConceptScore W3139453677C16930146 @default.
- W3139453677 hasConceptScore W3139453677C204232928 @default.
- W3139453677 hasConceptScore W3139453677C207103383 @default.
- W3139453677 hasConceptScore W3139453677C207886595 @default.
- W3139453677 hasConceptScore W3139453677C2778024521 @default.
- W3139453677 hasConceptScore W3139453677C2779306644 @default.
- W3139453677 hasConceptScore W3139453677C2781182431 @default.
- W3139453677 hasConceptScore W3139453677C44249647 @default.
- W3139453677 hasConceptScore W3139453677C50382708 @default.
- W3139453677 hasConceptScore W3139453677C52124034 @default.