FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3139467324> ?p ?o ?g. }

• W3139467324 endingPage "111517" @default.
• W3139467324 startingPage "111517" @default.
• W3139467324 abstract "Several brain neurotransmitters, including histamine (HA), acetylcholine (ACh), and dopamine (DA) are suggested to be involved in several brain disorders including cognitive deficits, depression, schizophrenia, anxiety, and narcolepsy, all of which are comorbid with Autism spectrum disorder (ASD). Therefore, the ameliorative effects of the novel multiple-active compound ST-713 with high binding affinities at histamine H3 receptor (H3R), dopamine D2sR and D3R on ASD-like behaviors in male BTBR T+tf/J mice model were assessed. ST-713 (3-(2-chloro-10H-phenothiazin-10-yl)-N-methyl-N-(4-(3-(piperidin-1-yl)propoxy)benzyl)propan-1-amine; 2.5, 5, and 10 mg/kg, i.p.) ameliorated dose-dependently social deficits, and significantly alleviated the repetitive/compulsive behaviors of BTBR mice (all P < 0.05). Moreover, ST-713 modulated disturbed anxiety levels, but failed to obliterate increased hyperactivity of tested mice. Furthermore, ST-713 (5 mg/kg) attenuated the increased levels of hippocampal and cerebellar protein expressions of NF-κB p65, COX-2, and iNOS in BTBR mice (all P < 0.05). The ameliorative effects of ST-713 on social parameters were entirely reversed by co-administration of the H3R agonist (R)-α-methylhistamine or the anticholinergic drug scopolamine. The obtained results demonstrate the potential of multiple-active compounds for the therapeutic management of neuropsychiatric disorders, e.g. ASD." @default.
• W3139467324 created "2021-03-29" @default.
• W3139467324 creator A5006857997 @default.
• W3139467324 creator A5009668124 @default.
• W3139467324 creator A5011317903 @default.
• W3139467324 creator A5016614839 @default.
• W3139467324 creator A5034401167 @default.
• W3139467324 creator A5059633215 @default.
• W3139467324 creator A5069973721 @default.
• W3139467324 creator A5080224708 @default.
• W3139467324 date "2021-06-01" @default.
• W3139467324 modified "2023-10-16" @default.
• W3139467324 title "The histamine H3R and dopamine D2R/D3R antagonist ST-713 ameliorates autism-like behavioral features in BTBR T+tf/J mice by multiple actions" @default.
• W3139467324 cites W1481790771 @default.
• W3139467324 cites W1749706763 @default.
• W3139467324 cites W1966037459 @default.
• W3139467324 cites W1966784044 @default.
• W3139467324 cites W1978341764 @default.
• W3139467324 cites W1979866975 @default.
• W3139467324 cites W1981775239 @default.
• W3139467324 cites W1994710518 @default.
• W3139467324 cites W2011944029 @default.
• W3139467324 cites W2014225402 @default.
• W3139467324 cites W2016079923 @default.
• W3139467324 cites W2016411894 @default.
• W3139467324 cites W2021202989 @default.
• W3139467324 cites W2022654189 @default.
• W3139467324 cites W2024121244 @default.
• W3139467324 cites W2025552546 @default.
• W3139467324 cites W2026674010 @default.
• W3139467324 cites W2029283970 @default.
• W3139467324 cites W2032011914 @default.
• W3139467324 cites W2034220807 @default.
• W3139467324 cites W2035339084 @default.
• W3139467324 cites W2045964345 @default.
• W3139467324 cites W2052424568 @default.
• W3139467324 cites W2059010901 @default.
• W3139467324 cites W2060497829 @default.
• W3139467324 cites W2071488844 @default.
• W3139467324 cites W2071797996 @default.
• W3139467324 cites W2072231159 @default.
• W3139467324 cites W2077687762 @default.
• W3139467324 cites W2082034244 @default.
• W3139467324 cites W2082109123 @default.
• W3139467324 cites W2083048709 @default.
• W3139467324 cites W2085352582 @default.
• W3139467324 cites W2087547434 @default.
• W3139467324 cites W2091991835 @default.
• W3139467324 cites W2100456941 @default.
• W3139467324 cites W2102773142 @default.
• W3139467324 cites W2103275395 @default.
• W3139467324 cites W2109181563 @default.
• W3139467324 cites W2111346020 @default.
• W3139467324 cites W2114038822 @default.
• W3139467324 cites W2127620928 @default.
• W3139467324 cites W2130433101 @default.
• W3139467324 cites W2139174791 @default.
• W3139467324 cites W2140287403 @default.
• W3139467324 cites W2144236040 @default.
• W3139467324 cites W2154385453 @default.
• W3139467324 cites W2154767575 @default.
• W3139467324 cites W2164253073 @default.
• W3139467324 cites W2170968899 @default.
• W3139467324 cites W2214916842 @default.
• W3139467324 cites W2337392459 @default.
• W3139467324 cites W2412142904 @default.
• W3139467324 cites W2464964435 @default.
• W3139467324 cites W2508580972 @default.
• W3139467324 cites W2563433357 @default.
• W3139467324 cites W2591245062 @default.
• W3139467324 cites W2601703801 @default.
• W3139467324 cites W2613763984 @default.
• W3139467324 cites W2617690685 @default.
• W3139467324 cites W2739669908 @default.
• W3139467324 cites W2762167966 @default.
• W3139467324 cites W2803899179 @default.
• W3139467324 cites W2888741274 @default.
• W3139467324 cites W2889275022 @default.
• W3139467324 cites W2894496459 @default.
• W3139467324 cites W2966577073 @default.
• W3139467324 cites W3033869116 @default.
• W3139467324 cites W3034711020 @default.
• W3139467324 cites W3082531461 @default.
• W3139467324 cites W3113982787 @default.
• W3139467324 cites W4211249129 @default.
• W3139467324 doi "https://doi.org/10.1016/j.biopha.2021.111517" @default.
• W3139467324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33773463" @default.
• W3139467324 hasPublicationYear "2021" @default.
• W3139467324 type Work @default.
• W3139467324 sameAs 3139467324 @default.
• W3139467324 citedByCount "11" @default.
• W3139467324 countsByYear W31394673242021 @default.
• W3139467324 countsByYear W31394673242022 @default.
• W3139467324 countsByYear W31394673242023 @default.
• W3139467324 crossrefType "journal-article" @default.
• W3139467324 hasAuthorship W3139467324A5006857997 @default.
• W3139467324 hasAuthorship W3139467324A5009668124 @default.
• W3139467324 hasAuthorship W3139467324A5011317903 @default.

• next