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- W3139470225 abstract "Clinical and epidemiological studies have suggested systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are comorbidities and common genetic etiologies can partly explain such coexistence. However, shared genetic determinations underlying the two diseases remain largely unknown.Our analysis relied on summary statistics available from genome-wide association studies of SLE (N = 23,210) and RA (N = 58,284). We first evaluated the genetic correlation between RA and SLE through the linkage disequilibrium score regression (LDSC). Then, we performed a multiple-tissue eQTL (expression quantitative trait loci) weighted integrative analysis for each of the two diseases and aggregated association evidence across these tissues via the recently proposed harmonic mean P-value (HMP) combination strategy, which can produce a single well-calibrated P-value for correlated test statistics. Afterwards, we conducted the pleiotropy-informed association using conjunction conditional FDR (ccFDR) to identify potential pleiotropic genes associated with both RA and SLE.We found there existed a significant positive genetic correlation (rg = 0.404, P = 6.01E-10) via LDSC between RA and SLE. Based on the multiple-tissue eQTL weighted integrative analysis and the HMP combination across various tissues, we discovered 14 potential pleiotropic genes by ccFDR, among which four were likely newly novel genes (i.e., INPP5B, OR5K2, RP11-2C24.5, and CTD-3105H18.4). The SNP effect sizes of these pleiotropic genes were typically positively dependent, with an average correlation of 0.579. Functionally, these genes were implicated in multiple auto-immune relevant pathways such as inositol phosphate metabolic process, membrane and glucagon signaling pathway.This study reveals common genetic components between RA and SLE and provides candidate associated loci for understanding of molecular mechanism underlying the comorbidity of the two diseases." @default.
- W3139470225 created "2021-03-29" @default.
- W3139470225 creator A5010438328 @default.
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- W3139470225 creator A5091819937 @default.
- W3139470225 date "2021-03-18" @default.
- W3139470225 modified "2023-09-27" @default.
- W3139470225 title "Detection of Genetic Overlap Between Rheumatoid Arthritis and Systemic Lupus Erythematosus Using GWAS Summary Statistics" @default.
- W3139470225 cites W1518966484 @default.
- W3139470225 cites W1533942137 @default.
- W3139470225 cites W1574244515 @default.
- W3139470225 cites W1601337698 @default.
- W3139470225 cites W1826234378 @default.
- W3139470225 cites W1847429134 @default.
- W3139470225 cites W1963639770 @default.
- W3139470225 cites W1966504829 @default.
- W3139470225 cites W1972985967 @default.
- W3139470225 cites W1980991473 @default.
- W3139470225 cites W1985934773 @default.
- W3139470225 cites W1989360964 @default.
- W3139470225 cites W1989590412 @default.
- W3139470225 cites W1990139289 @default.
- W3139470225 cites W1994612929 @default.
- W3139470225 cites W2001773683 @default.
- W3139470225 cites W2008047653 @default.
- W3139470225 cites W2009144436 @default.
- W3139470225 cites W2009588715 @default.
- W3139470225 cites W2019983262 @default.
- W3139470225 cites W2037010889 @default.
- W3139470225 cites W2041113577 @default.
- W3139470225 cites W2041953582 @default.
- W3139470225 cites W2047992550 @default.
- W3139470225 cites W2049429524 @default.
- W3139470225 cites W2052250022 @default.
- W3139470225 cites W2063655230 @default.
- W3139470225 cites W2068463156 @default.
- W3139470225 cites W2069646839 @default.
- W3139470225 cites W2072408668 @default.
- W3139470225 cites W2072651272 @default.
- W3139470225 cites W2086062071 @default.
- W3139470225 cites W2087936498 @default.
- W3139470225 cites W2091943129 @default.
- W3139470225 cites W2094525780 @default.
- W3139470225 cites W2104549677 @default.
- W3139470225 cites W2107373547 @default.
- W3139470225 cites W2107958379 @default.
- W3139470225 cites W2109003746 @default.
- W3139470225 cites W2117446594 @default.
- W3139470225 cites W2120385612 @default.
- W3139470225 cites W2120483845 @default.
- W3139470225 cites W2123725293 @default.
- W3139470225 cites W2126510876 @default.
- W3139470225 cites W2131220803 @default.
- W3139470225 cites W2136969237 @default.
- W3139470225 cites W2138282709 @default.
- W3139470225 cites W2141527784 @default.
- W3139470225 cites W2150157940 @default.
- W3139470225 cites W2163735374 @default.
- W3139470225 cites W2163749231 @default.
- W3139470225 cites W2163953557 @default.
- W3139470225 cites W2164143816 @default.
- W3139470225 cites W2166774283 @default.
- W3139470225 cites W2168781986 @default.
- W3139470225 cites W2169904625 @default.
- W3139470225 cites W2195783463 @default.
- W3139470225 cites W224511669 @default.
- W3139470225 cites W2264585211 @default.
- W3139470225 cites W2290434740 @default.
- W3139470225 cites W2297994856 @default.
- W3139470225 cites W2403080226 @default.
- W3139470225 cites W2405422196 @default.
- W3139470225 cites W2460126719 @default.
- W3139470225 cites W2464641366 @default.
- W3139470225 cites W2540109840 @default.
- W3139470225 cites W2553123256 @default.
- W3139470225 cites W2615367339 @default.
- W3139470225 cites W2618023053 @default.
- W3139470225 cites W2707240043 @default.
- W3139470225 cites W2725988230 @default.
- W3139470225 cites W2734773839 @default.
- W3139470225 cites W2747382797 @default.
- W3139470225 cites W2754593315 @default.
- W3139470225 cites W2759086237 @default.
- W3139470225 cites W2761940892 @default.
- W3139470225 cites W2773800864 @default.
- W3139470225 cites W2781509502 @default.
- W3139470225 cites W2782299002 @default.
- W3139470225 cites W2782675972 @default.
- W3139470225 cites W2789901287 @default.
- W3139470225 cites W2793935388 @default.
- W3139470225 cites W2802367710 @default.
- W3139470225 cites W2889044915 @default.
- W3139470225 cites W2889418962 @default.
- W3139470225 cites W2905951514 @default.
- W3139470225 cites W2907099021 @default.
- W3139470225 cites W2932783031 @default.