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- W3139537696 endingPage "387" @default.
- W3139537696 startingPage "387" @default.
- W3139537696 abstract "Acinetobacter baumannii is regarded as a life-threatening pathogen associated with community-acquired and nosocomial infections, mainly pneumonia. The rise in the number of A. baumannii antibiotic-resistant strains reduces effective therapies and increases mortality. Bacterial comparative genomic studies have unraveled the innate and acquired virulence factors of A. baumannii. These virulence factors are involved in antibiotic resistance, environmental persistence, host-pathogen interactions, and immune evasion. Studies on host–pathogen interactions revealed that A. baumannii evolved different mechanisms to adhere to in order to invade host respiratory cells as well as evade the host immune system. In this review, we discuss current data on A. baumannii genetic features and virulence factors. An emphasis is given to the players in host–pathogen interaction in the respiratory tract. In addition, we report recent investigations into host defense systems using in vitro and in vivo models, providing new insights into the innate immune response to A. baumannii infections. Increasing our knowledge of A. baumannii pathogenesis may help the development of novel therapeutic strategies based on anti-adhesive, anti-virulence, and anti-cell to cell signaling pathways drugs." @default.
- W3139537696 created "2021-03-29" @default.
- W3139537696 creator A5020630529 @default.
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- W3139537696 creator A5047634897 @default.
- W3139537696 creator A5075398108 @default.
- W3139537696 creator A5083357392 @default.
- W3139537696 date "2021-03-24" @default.
- W3139537696 modified "2023-10-18" @default.
- W3139537696 title "Acinetobacter baumannii: An Ancient Commensal with Weapons of a Pathogen" @default.
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