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- W3139596346 abstract "'Diabesity' refers to a rising epidemic indicated by the intricate relationship between obesity and diabetes. The global prevalence of these coexisting, insidious diseases increases social and economic health burdens at a rapid pace. Numerous reports delineate the involvement of the underlying endocannabinoid (EC) signaling system through the cannabinoid-1 (CB1) receptor in the regulation of metabolism and adiposity. Conversely, EC inverse agonists can result in severe depression and suicidal thoughts through interactions with CB1/2 receptors in the brain. This review attempts to elucidate a possible mechanism for the amelioration of diabesity. Moreover, we also highlight the available targets of the CB1 receptor, which could pave the way for safe and effective therapy." @default.
- W3139596346 created "2021-04-13" @default.
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- W3139596346 date "2021-07-01" @default.
- W3139596346 modified "2023-10-17" @default.
- W3139596346 title "Targeting the endocannabinoid system in diabesity: Fact or fiction?" @default.
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- W3139596346 doi "https://doi.org/10.1016/j.drudis.2021.03.022" @default.
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