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• W3139609946 abstract "Echinacoside(ECH) is protective in a mouse model of Parkinson’s disease(PD) induced by 1-methyl-4-phenylpyridinium ion(MPP~+). To investigate the mechanisms involved, SH-SY5Y neuroblastoma cells were treated with MPP~+or a combination of MPP~+and ECH,and the expression of ATF3(activating transcription factor3), CHOP(C/EBP-homologous protein), SCNA(synuclein alpha), and GDNF(glial cell line-derived neurotrophic factor) was assessed. The results showed that ECH significantly improved cell survival by inhibiting the generation of MPP~+-induced reactive oxygen species(ROS). In addition, ECH suppressed the ROS and MPP~+-induced expression of apoptotic genes(ATF3, CHOP, and SCNA). ECH markedly decreased the MPP~+-induced caspase-3 activity in a dose-dependent manner. ATF3-knockdown also decreased the CHOP and cleaved caspase-3 levels and inhibited the apoptosis induced by MPP~+.Interestingly, ECH partially restored the GDNF expression that was down-regulated by MPP~+. ECH also improved dopaminergic neuron survival during MPP~+treatment and protected these neurons against the apoptosis induced by MPTP. Taken together, these data suggest that the ROS/ATF3/CHOP pathway plays a critical role in mechanisms by which ECH protects against MPP~+-induced apoptosis in PD." @default.
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• W3139609946 date "2016-01-01" @default.
• W3139609946 modified "2023-09-24" @default.
• W3139609946 title "Echinacoside Protects Against MPP＋-Induced Neuronal Apoptosis via ROS/ATF3/CHOP Pathway Regulation" @default.
• W3139609946 hasPublicationYear "2016" @default.
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