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- W3139628512 abstract "Objective To explore the graft versus leukemia effects of donor lymphocyte infusion(DLI) after nonmyeloablative allogeneic bone marrow transplantation while attenuating treatment associated morbidity, mortality and graft versus host disease. Methods 615(H 2 k) mice were loaded with L615 cells and 3 days later received total body irradiation (TBI) 5Gy ( 60 Co γ ray) followed by allogeneic bone marrow transplantation (allo BMT). The allo grafts consisted of 3×10 7 bone marrow cells and 1×10 7 spleen cells from BALB/c (H 2 d) donor mice. Two days after allo BMT,the recipient mice were given 200mg/kg of CTX. Afterwards these recipient mice were infused either donor spleen cells (2×10 7) on d14 and d21 or hydrocortison (HC) and cyclosporine A (CsA) treated donor spleen cells (5×10 7) on d14 post BMT. Results Survival time of mice received DLI on d 21 and pretreated DLI on d14 post BMT was longer than that of control group and d14 DLI group(P0.01) and without severe graft versus host disease. Conclusion Donor lymphocyte infusion after nonmyeloablative bone marrow transplantation could reduce transplantation associated morbidity and mortality while strengthening graft versus leukemia effects." @default.
- W3139628512 created "2021-04-13" @default.
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- W3139628512 date "2001-01-01" @default.
- W3139628512 modified "2023-09-22" @default.
- W3139628512 title "Study on graft-versus-leukemia effects of donor lymphocyte infusion after nonmyeloablative allogeneic bone marrow transplantation" @default.
- W3139628512 hasPublicationYear "2001" @default.
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