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- W3139632460 abstract "Objective: To evaluate the single-dose tolerance and safety of intravenous ursolic acid nanoliposome.Methods: In 7 dose groups,the doses of ursolic acid nanoliposome were increased from 11mg·m-2 to 22,37,56,74,98 and 130mg·m-2.The tolerance and safety at 1,2,4,6 and 8,12,24 and 72 h after the single-dose administration were assessed based on changes in vital signs and clinical symptoms,and physico-chemical examination at 24 and 72 h after administration.Results: The maximum intravenous single-dose of ursolic acid nanoliposome was up to 130mg·m-2.The main toxic reactions were hepatotoxicity and diarrhea,other reactions included abdominal distension,nausea,dyslipidemia,serum sodium elevation,microscopic hematuria,skin allergy and vascular irritation.Conclusion: The maximum tolerable dose of intravenous ursolic acid nanoliposome is 98mg·m-2,and the dose-limiting toxicity is hepatotoxicity and diarrhea." @default.
- W3139632460 created "2021-04-13" @default.
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- W3139632460 date "2011-01-01" @default.
- W3139632460 modified "2023-09-23" @default.
- W3139632460 title "A phase I clinical trial of ursolic acid nanoliposome for evaluating its single-dose tolerance and safety" @default.
- W3139632460 hasPublicationYear "2011" @default.
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