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- W3139661647 abstract "背景众多的 mitochondrial DNA 变化显著地与糖尿病的开发被相关。这研究调查了 mitochondrial 基因，在有类型 2 糖尿病和他们的家庭的病人的点变化。有类型 2 糖尿病(n=826 ) 的方法无关的病人随机被招募；无关并且 nondiabetic 题目(n=637 ) 用作控制。参加者的临床、生物化学的数据是镇定的。全部的染色体从外部白细胞被提取。聚合酶链反应，限制碎片长度多型性(PCR-RFLP ) 和 clonig 技术被用来在 tRNALeu (UUR ) 在 ND1 区域和 np3243 包括 np3316， np3394 和 np3426 屏蔽 mitochondrial 基因。在有至少一 mitochondrial 基因的 39 名糖尿病患者的结果削尖变化， mtDNA 变化的流行(4.7%,39/826 ) 比那高(0.7%,5/637 ) 在控制。相同变化从三个家谱在 43 个测试成员中的 23 个被发现。影响家庭成员介绍了，可变临床的特征从正常葡萄糖忍耐到损害葡萄糖忍耐(IGT )(n=2 ) ，损害 fasting 葡萄糖(IFG )(n=1 ) 到与受不了听觉损失的 3 个家庭成员一起的类型 2 糖尿病(n=13 ) 。在中国的结论类型 2 糖尿病与几个 mitochondrial 基因变化被联系。有糖尿病的家庭历史的年老的病人有变化和各种各样的临床的图画的更高的流行。Mitochondrial 基因变化可能是贡献糖尿病的家庭聚类的基因因素之一。" @default.
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- W3139661647 date "2008-01-01" @default.
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- W3139661647 title "Mitochondrial gene mutations and type 2 diabetes in Chinese families" @default.
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