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- W3139724466 abstract "textabstractSince the development of transplantation of tissues, much effort has beendirected towards the acceptance of transplanted grafts. Many methods havebeen developed to prevent or delay the rejection reaction. Some of them areused in clinical transplantation, involving immunosuppression of the host bycertain drugs, hormones and by anti lymphocyte serum, which contains antibodiesdirected against the lymphocytes of the host. These methods, if carefullyapplied, may indeed prevent rejection of the grafts in a proportion ofthe patients. However, treatment with these drugs can be deleterious for thehost, for suppression of the immune response increases the susceptibility forinfection and probably also for tumors. In fact, many recipients of organtransplants still die from sepsis.Thus, any type of immunosuppression is still associated with a noxious effecton the host. A solution for these transplantation problems might be providedby the oldest principle in the achievement of graft acceptance, namely enhancement.Recently Snell defined enhancement as: the enhanced or prolongedgrowths of allografts, due to the presence in the graft recipient of allo-antibodydirected against the allo-antigens of the donor. In other words, a graft isprotected by enhancing antibodies, that are not directed against the recipientas is the case for A.L.S., but against the donor antigens." @default.
- W3139724466 created "2021-04-13" @default.
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- W3139724466 date "1972-01-26" @default.
- W3139724466 modified "2023-09-26" @default.
- W3139724466 title "Immunological enhancement of skin allo- and heterografts" @default.
- W3139724466 hasPublicationYear "1972" @default.
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