FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3139739862> ?p ?o ?g. }

• W3139739862 abstract "Background: In patients with chronic obstructive pulmonary disease (COPD), acute exacerbations affect patients' health and can lead to death. This study was aimed to develop a prediction model for in-hospital mortality in patients with acute exacerbations of COPD (AECOPD). Method: A retrospective study was performed in patients hospitalized for AECOPD between 2015 and 2019. Patients admitted between 2015 and 2017 were included to develop model and individuals admitted in the following 2 years were included for external validation. We analyzed variables that were readily available in clinical practice. Given that death was a rare outcome in this study, we fitted Firth penalized logistic regression. C statistic and calibration plot quantified the model performance. Optimism-corrected C statistic and slope were estimated by bootstrapping. Accordingly, the prediction model was adjusted and then transformed into risk score. Result: Between 2015 and 2017, 1,096 eligible patients were analyzed, with a mean age of 73 years and 67.8% male. The in-hospital mortality was 2.6%. Compared to survivors, non-survivors were older, more admitted from emergency, more frequently concomitant with respiratory failure, pneumothorax, hypoxic-hypercarbic encephalopathy, and had longer length of stay (LOS). Four variables were included into the final model: age, respiratory failure, pneumothorax, and LOS. In internal validation, C statistic was 0.9147, and the calibration slope was 1.0254. Their optimism-corrected values were 0.90887 and 0.9282, respectively, indicating satisfactory discrimination and calibration. When externally validated in 700 AECOPD patients during 2018 and 2019, the model demonstrated good discrimination with a C statistic of 0.8176. Calibration plot illustrated a varying discordance between predicted and observed mortality. It demonstrated good calibration in low-risk patients with predicted mortality rate ≤10% ( P = 0.3253) but overestimated mortality in patients with predicted rate &gt;10% ( P &lt; 0.0001). The risk score of 20 was regarded as a threshold with an optimal Youden index of 0.7154. Conclusion: A simple prediction model for AECOPD in-hospital mortality has been developed and externally validated. Based on available data in clinical setting, the model could serve as an easily used instrument for clinical decision-making. Complications emerged as strong predictors, underscoring an important role of disease management in improving patients' prognoses during exacerbation episodes." @default.
• W3139739862 created "2021-04-13" @default.
• W3139739862 creator A5008228591 @default.
• W3139739862 creator A5027080880 @default.
• W3139739862 creator A5044794520 @default.
• W3139739862 creator A5047350019 @default.
• W3139739862 creator A5082730685 @default.
• W3139739862 creator A5091550310 @default.
• W3139739862 date "2021-04-06" @default.
• W3139739862 modified "2023-09-25" @default.
• W3139739862 title "Development and Validation of Risk Prediction Model for In-hospital Mortality Among Patients Hospitalized With Acute Exacerbation Chronic Obstructive Pulmonary Disease Between 2015 and 2019" @default.
• W3139739862 cites W1868068011 @default.
• W3139739862 cites W1994224528 @default.
• W3139739862 cites W1994682257 @default.
• W3139739862 cites W2037195555 @default.
• W3139739862 cites W2062568880 @default.
• W3139739862 cites W2094759104 @default.
• W3139739862 cites W2112162293 @default.
• W3139739862 cites W2113540946 @default.
• W3139739862 cites W2119612035 @default.
• W3139739862 cites W2129238234 @default.
• W3139739862 cites W2134187827 @default.
• W3139739862 cites W2134232280 @default.
• W3139739862 cites W2144652900 @default.
• W3139739862 cites W2150615401 @default.
• W3139739862 cites W2150789350 @default.
• W3139739862 cites W2163204093 @default.
• W3139739862 cites W2171642892 @default.
• W3139739862 cites W2304501075 @default.
• W3139739862 cites W2772075642 @default.
• W3139739862 cites W2798095897 @default.
• W3139739862 cites W2802349616 @default.
• W3139739862 cites W2898559532 @default.
• W3139739862 cites W3012413426 @default.
• W3139739862 cites W3023340082 @default.
• W3139739862 cites W3029773363 @default.
• W3139739862 cites W3083838360 @default.
• W3139739862 doi "https://doi.org/10.3389/fmed.2021.630870" @default.
• W3139739862 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8055833" @default.
• W3139739862 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33889584" @default.
• W3139739862 hasPublicationYear "2021" @default.
• W3139739862 type Work @default.
• W3139739862 sameAs 3139739862 @default.
• W3139739862 citedByCount "5" @default.
• W3139739862 countsByYear W31397398622021 @default.
• W3139739862 countsByYear W31397398622022 @default.
• W3139739862 countsByYear W31397398622023 @default.
• W3139739862 crossrefType "journal-article" @default.
• W3139739862 hasAuthorship W3139739862A5008228591 @default.
• W3139739862 hasAuthorship W3139739862A5027080880 @default.
• W3139739862 hasAuthorship W3139739862A5044794520 @default.
• W3139739862 hasAuthorship W3139739862A5047350019 @default.
• W3139739862 hasAuthorship W3139739862A5082730685 @default.
• W3139739862 hasAuthorship W3139739862A5091550310 @default.
• W3139739862 hasBestOaLocation W31397398621 @default.
• W3139739862 hasConcept C126322002 @default.
• W3139739862 hasConcept C151956035 @default.
• W3139739862 hasConcept C177713679 @default.
• W3139739862 hasConcept C194828623 @default.
• W3139739862 hasConcept C2776780178 @default.
• W3139739862 hasConcept C2777014857 @default.
• W3139739862 hasConcept C71924100 @default.
• W3139739862 hasConceptScore W3139739862C126322002 @default.
• W3139739862 hasConceptScore W3139739862C151956035 @default.
• W3139739862 hasConceptScore W3139739862C177713679 @default.
• W3139739862 hasConceptScore W3139739862C194828623 @default.
• W3139739862 hasConceptScore W3139739862C2776780178 @default.
• W3139739862 hasConceptScore W3139739862C2777014857 @default.
• W3139739862 hasConceptScore W3139739862C71924100 @default.
• W3139739862 hasLocation W31397398621 @default.
• W3139739862 hasLocation W31397398622 @default.
• W3139739862 hasOpenAccess W3139739862 @default.
• W3139739862 hasPrimaryLocation W31397398621 @default.
• W3139739862 hasRelatedWork W1974526650 @default.
• W3139739862 hasRelatedWork W2052775590 @default.
• W3139739862 hasRelatedWork W2069826751 @default.
• W3139739862 hasRelatedWork W2077638660 @default.
• W3139739862 hasRelatedWork W2187214054 @default.
• W3139739862 hasRelatedWork W2409754429 @default.
• W3139739862 hasRelatedWork W2540794235 @default.
• W3139739862 hasRelatedWork W2779821228 @default.
• W3139739862 hasRelatedWork W4386452014 @default.
• W3139739862 hasRelatedWork W2127760953 @default.
• W3139739862 hasVolume "8" @default.
• W3139739862 isParatext "false" @default.
• W3139739862 isRetracted "false" @default.
• W3139739862 magId "3139739862" @default.
• W3139739862 workType "article" @default.