Matches in SemOpenAlex for { <https://semopenalex.org/work/W3139765622> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W3139765622 endingPage "264" @default.
- W3139765622 startingPage "255" @default.
- W3139765622 abstract "Recent research has demonstrated that advanced liver fibrosis in patients could be reversed, but no approved agents are available for the treatment and prevention of liver fibrosis in humans. Curcumin(CUR) is the principal curcuminoid of turmeric. Inhibitory effects of CUR and its underlying mechanisms in liver fibrogenesis have been explored. In the present study, we hypothesized that epigenetic mechanisms contribute to the protective effects of CUR against liver fibrosis. We used CCl4-induced liver injury in BALB/c mice and the rat hepatic stellate cell line HSC-T6 as experimental models. Genomic DNA methylation was analyzed by Me DIP-chip and verified by real-time PCR on Me DIP-enriched DNA. The m RNA and protein expressions of DNMT1, α-SMA, and Col1α1 were determined by real-time PCR and Western blotting, respectively. The methylation statuses of FGFR3, FZD10, Gpx4, and Hoxd3 were further confirmed by quantitative methylation-specific PCR(q MSP). Our results showed that CUR treatment reversed liver injury in vivo and in vitro, possibly through down regulation of DNMT1, α-SMA, and Col1α1 and by demethylation of the key genes. In conclusion, aberrant methylation is closely associated with liver fibrosis and CUR treatment may reverse liver fibrosis by epigenetic mechanisms." @default.
- W3139765622 created "2021-04-13" @default.
- W3139765622 creator A5016427396 @default.
- W3139765622 creator A5031774992 @default.
- W3139765622 creator A5036213114 @default.
- W3139765622 creator A5037474620 @default.
- W3139765622 creator A5051552423 @default.
- W3139765622 creator A5058824666 @default.
- W3139765622 creator A5071540194 @default.
- W3139765622 date "2016-01-01" @default.
- W3139765622 modified "2023-09-23" @default.
- W3139765622 title "Protective effects of curcumin against liver fibrosis through modulating DNA methylation" @default.
- W3139765622 hasPublicationYear "2016" @default.
- W3139765622 type Work @default.
- W3139765622 sameAs 3139765622 @default.
- W3139765622 citedByCount "0" @default.
- W3139765622 crossrefType "journal-article" @default.
- W3139765622 hasAuthorship W3139765622A5016427396 @default.
- W3139765622 hasAuthorship W3139765622A5031774992 @default.
- W3139765622 hasAuthorship W3139765622A5036213114 @default.
- W3139765622 hasAuthorship W3139765622A5037474620 @default.
- W3139765622 hasAuthorship W3139765622A5051552423 @default.
- W3139765622 hasAuthorship W3139765622A5058824666 @default.
- W3139765622 hasAuthorship W3139765622A5071540194 @default.
- W3139765622 hasConcept C104317684 @default.
- W3139765622 hasConcept C134018914 @default.
- W3139765622 hasConcept C142724271 @default.
- W3139765622 hasConcept C150194340 @default.
- W3139765622 hasConcept C153911025 @default.
- W3139765622 hasConcept C176891718 @default.
- W3139765622 hasConcept C185592680 @default.
- W3139765622 hasConcept C190727270 @default.
- W3139765622 hasConcept C207001950 @default.
- W3139765622 hasConcept C2776637226 @default.
- W3139765622 hasConcept C2777070074 @default.
- W3139765622 hasConcept C2778250585 @default.
- W3139765622 hasConcept C2780559512 @default.
- W3139765622 hasConcept C33288867 @default.
- W3139765622 hasConcept C41091548 @default.
- W3139765622 hasConcept C502942594 @default.
- W3139765622 hasConcept C54355233 @default.
- W3139765622 hasConcept C552990157 @default.
- W3139765622 hasConcept C55493867 @default.
- W3139765622 hasConcept C71924100 @default.
- W3139765622 hasConcept C86803240 @default.
- W3139765622 hasConcept C98274493 @default.
- W3139765622 hasConceptScore W3139765622C104317684 @default.
- W3139765622 hasConceptScore W3139765622C134018914 @default.
- W3139765622 hasConceptScore W3139765622C142724271 @default.
- W3139765622 hasConceptScore W3139765622C150194340 @default.
- W3139765622 hasConceptScore W3139765622C153911025 @default.
- W3139765622 hasConceptScore W3139765622C176891718 @default.
- W3139765622 hasConceptScore W3139765622C185592680 @default.
- W3139765622 hasConceptScore W3139765622C190727270 @default.
- W3139765622 hasConceptScore W3139765622C207001950 @default.
- W3139765622 hasConceptScore W3139765622C2776637226 @default.
- W3139765622 hasConceptScore W3139765622C2777070074 @default.
- W3139765622 hasConceptScore W3139765622C2778250585 @default.
- W3139765622 hasConceptScore W3139765622C2780559512 @default.
- W3139765622 hasConceptScore W3139765622C33288867 @default.
- W3139765622 hasConceptScore W3139765622C41091548 @default.
- W3139765622 hasConceptScore W3139765622C502942594 @default.
- W3139765622 hasConceptScore W3139765622C54355233 @default.
- W3139765622 hasConceptScore W3139765622C552990157 @default.
- W3139765622 hasConceptScore W3139765622C55493867 @default.
- W3139765622 hasConceptScore W3139765622C71924100 @default.
- W3139765622 hasConceptScore W3139765622C86803240 @default.
- W3139765622 hasConceptScore W3139765622C98274493 @default.
- W3139765622 hasIssue "4" @default.
- W3139765622 hasLocation W31397656221 @default.
- W3139765622 hasOpenAccess W3139765622 @default.
- W3139765622 hasPrimaryLocation W31397656221 @default.
- W3139765622 hasRelatedWork W1960283802 @default.
- W3139765622 hasRelatedWork W1970409885 @default.
- W3139765622 hasRelatedWork W1993835933 @default.
- W3139765622 hasRelatedWork W2074750401 @default.
- W3139765622 hasRelatedWork W2170151746 @default.
- W3139765622 hasRelatedWork W2339641006 @default.
- W3139765622 hasRelatedWork W2466116628 @default.
- W3139765622 hasRelatedWork W2749257157 @default.
- W3139765622 hasRelatedWork W2765915906 @default.
- W3139765622 hasRelatedWork W2895074874 @default.
- W3139765622 hasRelatedWork W2946780309 @default.
- W3139765622 hasRelatedWork W2980425919 @default.
- W3139765622 hasRelatedWork W2996237031 @default.
- W3139765622 hasRelatedWork W3007343992 @default.
- W3139765622 hasRelatedWork W3036208866 @default.
- W3139765622 hasRelatedWork W3046107783 @default.
- W3139765622 hasRelatedWork W3132949254 @default.
- W3139765622 hasRelatedWork W3141875422 @default.
- W3139765622 hasRelatedWork W3160176245 @default.
- W3139765622 hasRelatedWork W3211379392 @default.
- W3139765622 hasVolume "14" @default.
- W3139765622 isParatext "false" @default.
- W3139765622 isRetracted "false" @default.
- W3139765622 magId "3139765622" @default.
- W3139765622 workType "article" @default.