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- W3139780822 abstract "OBJECTIVE:To determine the transcriptional expression of mitochondrial genome (mtDNA) in MGC803 cell lines subjected by various time-phase hypoxic dispositions, and further to discuss the influence of mtDNA transcripts on hypoxic resistance to irradiation. METHODS: RT-PCR was applied to detect the transcripts of COⅠ, ND4, ND5, cyt-b and ATPase6 in various time-phases of hypoxic MGC803 cell lines,followed by X-ray irradiation. The flow cytometry and colony forming method was conducted to evaluate the cell cycle phase and survival fraction. RESULTS: COⅠand ND4 transcripts of MGC803 cell lines were influenced remarkably by hypoxia. COⅠ transcripts decreased remarkably along with the elongation of hypoxic time, and reduced to one fourth of that in pre-hypoxia after hypoxia for 24 h. ND4 transcripts increased initially, and elevated to two folds after hypoxia for 8 h, and then reduced to one second after hypoxia for 24 h. Hypoxia resulted in G_1 phase blockage, especially after hypoxia for 16 h. The survival rate of MGC803 cells in irradiation group after hypoxia showed elevated tendency with prolonged hypoxia before irradiation. CONCLUSION: Hypoxic tumor cells with lower COⅠ and the ND4 expression levels have stronger resistance to radioactivity,referring that increasing its expression might be advantageous to enhance sensitivity of hypoxic tumor cells to radiotherapy." @default.
- W3139780822 created "2021-04-13" @default.
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- W3139780822 date "2006-01-01" @default.
- W3139780822 modified "2023-09-24" @default.
- W3139780822 title "Expression of mitochondrial transcripts in gastric MGC803 cell line subjected by hypoxia" @default.
- W3139780822 hasPublicationYear "2006" @default.
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