FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3139796002> ?p ?o ?g. }

• W3139796002 abstract "Objective To investigate the association between interleukin(IL)-1 gene cluster polymorphism and the genetic susceptibility for ankylosing spondylitis(AS).Methods Relevant published data were retrieved through Pubmed,EMBASE,Cochrance library and Chinese Bio-medicine Database (CBM).Studies eligible for this meta-analysis had to meet all the following inclusion criteria:(1)the content was associated with population-based case-control studies,(2)the study was on the relationship between the IL-1 gene cluster polymorphism and AS,(3)the diagnosis of AS was based on the modified New York criteria(1984)by the rheumatologist.(4)the raw data including the frequencies of alleles and certain genotypes in case and control groups could be collected,and(5)the distribution of studied loci in the populations was in accord with the Hardy-Meinberg equilibrium.Researches that didn't meet the inclusion criteria,as well as the duplicated reports,family-based studies were excluded.All analyses were conducted with the software 'Review Manager' Version 4.2.8.Results(1)A total of 6 literatures, including 9 population samples,were studied.The overall combined data were verified to be heterogeneous, and the heterogeneity disappeared after stratification by the race.Then,the fixed-effect model could be applied.(2)The combined data revealed the frequencies of allele 2 and its genotypes of IL-1RN intron 2 variable number of tendem repeats were higher in the AS groups than in the controls in the Caucasian population(allele 2:OR=1.52,95% CI=1.26～1.84,P0.01;genotype:OR=1.33,95% CI= 1.04～1.70,P0.05),but lower in the AS groups than in the controls in the Mongolian population(allele 2:OR=0.55,95% CI=0.38～0.81,P0.01;genotype:OR=0.51,95% CI=0.34～0.77,P 0.01).(3)The minor allele T of IL-1A-889CT(rs1800587)was higher in the AS group than in the controls in the Caucasian population(allele T:OR=1.36,95% CI=1.12～1.66,P0.01;genotype C/T+T/T:OR=1.56,95% CI=1.20～2.03,P0.01).This distribution could not be found in the Mongolian population for this SNP.(4)The minor allele G of IL-1 F8 SNP(rs1900287)was higher in the AS group than in the controls in the Caucasian population(OR=1.22,95% CI=1.04～1.44,P0.05). Conclusion The genetic susceptibility for AS may be associated with the IL-1 gene cluster polymorphism. The relevant polymorphic sites include IL-1RN 86bp VNTR in intron 2,IL-1A-889CT(rs1800587)and IL-1F8 SNP(rs1900287).Furthermore,there is a distinct discrepancy for this association among races." @default.
• W3139796002 created "2021-04-13" @default.
• W3139796002 creator A5045282942 @default.
• W3139796002 date "2007-01-01" @default.
• W3139796002 modified "2023-09-23" @default.
• W3139796002 title "A meta-analysis on interleukin-1 gene cluster polymorphism and genetic susceptibility for ankylosing spondylitis" @default.
• W3139796002 hasPublicationYear "2007" @default.
• W3139796002 type Work @default.
• W3139796002 sameAs 3139796002 @default.
• W3139796002 citedByCount "0" @default.
• W3139796002 crossrefType "journal-article" @default.
• W3139796002 hasAuthorship W3139796002A5045282942 @default.
• W3139796002 hasConcept C104317684 @default.
• W3139796002 hasConcept C126322002 @default.
• W3139796002 hasConcept C135763542 @default.
• W3139796002 hasConcept C149737253 @default.
• W3139796002 hasConcept C180754005 @default.
• W3139796002 hasConcept C2777402515 @default.
• W3139796002 hasConcept C2908647359 @default.
• W3139796002 hasConcept C54355233 @default.
• W3139796002 hasConcept C71924100 @default.
• W3139796002 hasConcept C76252995 @default.
• W3139796002 hasConcept C86803240 @default.
• W3139796002 hasConcept C95190672 @default.
• W3139796002 hasConcept C99454951 @default.
• W3139796002 hasConceptScore W3139796002C104317684 @default.
• W3139796002 hasConceptScore W3139796002C126322002 @default.
• W3139796002 hasConceptScore W3139796002C135763542 @default.
• W3139796002 hasConceptScore W3139796002C149737253 @default.
• W3139796002 hasConceptScore W3139796002C180754005 @default.
• W3139796002 hasConceptScore W3139796002C2777402515 @default.
• W3139796002 hasConceptScore W3139796002C2908647359 @default.
• W3139796002 hasConceptScore W3139796002C54355233 @default.
• W3139796002 hasConceptScore W3139796002C71924100 @default.
• W3139796002 hasConceptScore W3139796002C76252995 @default.
• W3139796002 hasConceptScore W3139796002C86803240 @default.
• W3139796002 hasConceptScore W3139796002C95190672 @default.
• W3139796002 hasConceptScore W3139796002C99454951 @default.
• W3139796002 hasLocation W31397960021 @default.
• W3139796002 hasOpenAccess W3139796002 @default.
• W3139796002 hasPrimaryLocation W31397960021 @default.
• W3139796002 hasRelatedWork W1552450008 @default.
• W3139796002 hasRelatedWork W1965657316 @default.
• W3139796002 hasRelatedWork W2035880703 @default.
• W3139796002 hasRelatedWork W2337521071 @default.
• W3139796002 hasRelatedWork W2368087260 @default.
• W3139796002 hasRelatedWork W2375346477 @default.
• W3139796002 hasRelatedWork W2380655650 @default.
• W3139796002 hasRelatedWork W2394644118 @default.
• W3139796002 hasRelatedWork W2400411874 @default.
• W3139796002 hasRelatedWork W2612499091 @default.
• W3139796002 hasRelatedWork W2794202897 @default.
• W3139796002 hasRelatedWork W2902514105 @default.
• W3139796002 hasRelatedWork W2965086005 @default.
• W3139796002 hasRelatedWork W3001093489 @default.
• W3139796002 hasRelatedWork W3026706157 @default.
• W3139796002 hasRelatedWork W3046909749 @default.
• W3139796002 hasRelatedWork W3128952640 @default.
• W3139796002 hasRelatedWork W765110762 @default.
• W3139796002 hasRelatedWork W2337664255 @default.
• W3139796002 hasRelatedWork W2551064073 @default.
• W3139796002 isParatext "false" @default.
• W3139796002 isRetracted "false" @default.
• W3139796002 magId "3139796002" @default.
• W3139796002 workType "article" @default.