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- W3139922218 abstract "背景肌球素专门在有条纹的骨胳的肌肉被表示并且在清除的氮的氧化物被含有。积累的数据在两个为氮的氧化物建议一个关键角色对局部缺血的内长、治疗学的 angiogenic 反应。为在 ischemic 的肌球素的一个清楚的角色骨胳的肌肉是不明确的。我们假设了那肌球素 overexpression 在对 ischemia.Methods 的 angiogenic 反应上有不利影响肌肉特定的肌球素过去表示的转基因的老鼠(MbTG， n=11 ) ，野类型同窝出生的人(WT， n=23 ) 经历了单方的大腿骨的动脉结扎和切除。激光 doppler 灌注成像被用来在外科以后在外科和周刊前在 hindlimb 灌注监视变化直到 28 天。织物局部缺血被坏死发生估计。在实验(在外科以后的 28 天)的结束之上，骨胳的肌肉( gastrocnemius ，和 tibialis 前面)被收获，肌肉的远侧的部分为组织学被冻结并且嵌入学习，近似部分也被使用检测脉管的 endothelial 生长有连接酶的 immunosorbent 试金( ELISA )或到的因素( VEGF )水平决定增长(增殖的电话原子抗原( PCNA ))并且 apoptosis ( Bax ，和 Bcl-2 )在由西方的弄污的 ischemic 肌肉的状况。Capillaries 与 endothelial 磷酸盐被染色碱的染色和脉管的密度在在 MbTG 老鼠的灌注的恢复是的 capillaries/fiber.Results 被表示类似于白天 7 上的 WT 老鼠的(0.485 ? 吗？？" @default.
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- W3139922218 date "2009-01-01" @default.
- W3139922218 modified "2023-09-23" @default.
- W3139922218 title "Myoglobin over-expression attenuates angiogenic response in hindlimb ischemia in mice" @default.
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