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- W3139925462 abstract "To study the influence of the serum cytokine levels of patients with Graves' disease（GD） before and After Treated With ~(131)I. Using the method of radioimmunoassay, the serum levels of interleukin-1 （IL-1）, interleukin-2 （IL-2）, interleukin-6（IL-6）, interleukin-8（IL-8） and tumor necrosis factor（TNF-alpha） of GD 52 patients were measured before and after ~(131)I, 30 age-and sex-matched healthy subjects served as controls, and the results were compared with that of the control group. The levels of IL-1, IL-6, IL-8, TNF-alpha of GD patients were significantly higher than that of the control group（P<0.01）, the levels of IL-2 of GD patients were significantly lower than that of the control group（P<0.01）. The serum IL-1, IL-8, IL-6, TNF-alpha levels of GD patients of after treated with ~(131)I were significantly lower than those before treatment（P<0.01）, whereas serum IL-2 level was higher （P<0.01）. The serum levels of IL-1, IL-6 positively correlated with FT3 （P<0.05）. There was a negative correlation between IL-2 and FI3 （P<0.05）. Successful ~(131)I therapy would effectively suppress the auto-immune status in GD patients; Cytokines play certain roles in the progressing of GD, and the serum cytokines levels might reflect the immune activity and be implicated in immunopathology Graves'disease and prognosis." @default.
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- W3139925462 date "2006-01-01" @default.
- W3139925462 modified "2023-09-23" @default.
- W3139925462 title "Dynamic study on the influence of the serum cytokine levels in patients with Graves' disease before and After Treated With ~(131)I" @default.
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