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- W3139933344 abstract "Objective To explore the impact of monocytes(MOs) stimulated by FⅫ on the invasion potential of EOC.Methods Monocytes isolated from female healthy donors were culture and stimulated with Factor Ⅻ for 12 h.Tumor associated macrophage(TAM) were derived from ascites of EOC.India ink engulfing test was used to detect phagocytic capacity of MOs stimulated by FⅫ.Invasive potential of EOC,including ES-2,SKOV-3,HO-8910 cells were investigated by Matrigel invasion assay.The signaling pathway involved in MOs activated by FⅫ were measured by Transfactor family Kits,including AP-1,STAT,Inflammation 1 and Oncogene 3.Results (1) The percentage of engulfing Indian ink were 0.66±0.04 in TAM and 0.36±0.03 in monocytes stimulated by FⅫ,which were significantly higher than that monocytes from healthy donors(0.27±0.018)(P0.01 and P=0.033).(2) ES-2 cells were shown more invasive cell number when the supernatant from MOs+Ⅻ was used as chemo-attractant(110.9±5.046),fewer than that of ascites group(157.5±14.86),but significantly more than that of negative control group in which cells were cultured with usual medium(39.14±10.91).When adding Centuximab into supernatants,decreased invasive cell numbers(42.43±9.097) were observed. Conclusion FⅫmight educate MOs differentiation toward TAM like cells,thus accelerated metastasis and invasion of EOC in the peritoneum." @default.
- W3139933344 created "2021-04-13" @default.
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- W3139933344 date "2009-01-01" @default.
- W3139933344 modified "2023-09-23" @default.
- W3139933344 title "Coagulation factor XII facilitate EOC cells invasion potential via stimulating IL-8 secretion from monocytes" @default.
- W3139933344 hasPublicationYear "2009" @default.
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