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- W3139966125 abstract "Notable advances in gene sequencing methods in recent years have permitted enormous progress in the phenotypic and genotypic characterization of autoinflammatory syndromes. Interferonopathies are a recent group of inherited autoinflammatory diseases, characterized by a dysregulation of the interferon pathway, leading to constitutive upregulation of its activation mechanisms or downregulation of negative regulatory systems. They are clinically heterogeneous, but some peculiar clinical features may lead to suspicion: a familial “idiopathic” juvenile arthritis resistant to conventional treatments, an early necrotizing vasculitis, a non-infectious interstitial lung disease, and a panniculitis associated or not with a lipodystrophy may represent the “interferon alarm bells.” The awareness of this group of diseases represents a challenge for pediatricians because, despite being rare, a differential diagnosis with the most common childhood rheumatological and immunological disorders is mandatory. Furthermore, the characterization of interferonopathy molecular pathogenetic mechanisms is allowing important steps forward in other immune dysregulation diseases, such as systemic lupus erythematosus and inflammatory myositis, implementing the opportunity of a more effective target therapy." @default.
- W3139966125 created "2021-04-13" @default.
- W3139966125 creator A5041941790 @default.
- W3139966125 creator A5060518463 @default.
- W3139966125 creator A5077451775 @default.
- W3139966125 creator A5088457404 @default.
- W3139966125 date "2021-03-31" @default.
- W3139966125 modified "2023-10-11" @default.
- W3139966125 title "Type I Interferonopathies in Children: An Overview" @default.
- W3139966125 cites W1498368498 @default.
- W3139966125 cites W1509658266 @default.
- W3139966125 cites W1538997551 @default.
- W3139966125 cites W1542158376 @default.
- W3139966125 cites W1567114372 @default.
- W3139966125 cites W1601709990 @default.
- W3139966125 cites W1623326406 @default.
- W3139966125 cites W1653486230 @default.
- W3139966125 cites W1708550902 @default.
- W3139966125 cites W1776390480 @default.
- W3139966125 cites W1965672602 @default.
- W3139966125 cites W1972526106 @default.
- W3139966125 cites W1973651901 @default.
- W3139966125 cites W1978748659 @default.
- W3139966125 cites W1982983059 @default.
- W3139966125 cites W1986036781 @default.
- W3139966125 cites W1987484835 @default.
- W3139966125 cites W1997125513 @default.
- W3139966125 cites W2000177767 @default.
- W3139966125 cites W2005476391 @default.
- W3139966125 cites W2010839055 @default.
- W3139966125 cites W2014438596 @default.
- W3139966125 cites W2015310325 @default.
- W3139966125 cites W2017760549 @default.
- W3139966125 cites W2019916852 @default.
- W3139966125 cites W2020173029 @default.
- W3139966125 cites W2029975301 @default.
- W3139966125 cites W2030785379 @default.
- W3139966125 cites W2031170591 @default.
- W3139966125 cites W2036329866 @default.
- W3139966125 cites W2044493383 @default.
- W3139966125 cites W2046413321 @default.
- W3139966125 cites W2057132009 @default.
- W3139966125 cites W2057150798 @default.
- W3139966125 cites W2060926084 @default.
- W3139966125 cites W2061173833 @default.
- W3139966125 cites W2061571837 @default.
- W3139966125 cites W2061952755 @default.
- W3139966125 cites W2065794552 @default.
- W3139966125 cites W2076690763 @default.
- W3139966125 cites W2076996690 @default.
- W3139966125 cites W2080775789 @default.
- W3139966125 cites W2082632613 @default.
- W3139966125 cites W2092184775 @default.
- W3139966125 cites W2092606926 @default.
- W3139966125 cites W2103433909 @default.
- W3139966125 cites W2105445844 @default.
- W3139966125 cites W2114895792 @default.
- W3139966125 cites W2128211133 @default.
- W3139966125 cites W2130449325 @default.
- W3139966125 cites W2133402546 @default.
- W3139966125 cites W2136400402 @default.
- W3139966125 cites W2138282259 @default.
- W3139966125 cites W2145978988 @default.
- W3139966125 cites W2147843065 @default.
- W3139966125 cites W2160849060 @default.
- W3139966125 cites W2162351951 @default.
- W3139966125 cites W2167017590 @default.
- W3139966125 cites W2167090083 @default.
- W3139966125 cites W2168888135 @default.
- W3139966125 cites W2168907450 @default.
- W3139966125 cites W2169830762 @default.
- W3139966125 cites W2171946670 @default.
- W3139966125 cites W2176625493 @default.
- W3139966125 cites W2325608780 @default.
- W3139966125 cites W2335335753 @default.
- W3139966125 cites W2337143478 @default.
- W3139966125 cites W2416747496 @default.
- W3139966125 cites W2419219541 @default.
- W3139966125 cites W2471963095 @default.
- W3139966125 cites W2516872413 @default.
- W3139966125 cites W2522784175 @default.
- W3139966125 cites W2556737993 @default.
- W3139966125 cites W2560204043 @default.
- W3139966125 cites W2564819117 @default.
- W3139966125 cites W2580973364 @default.
- W3139966125 cites W2596476214 @default.
- W3139966125 cites W2600253196 @default.
- W3139966125 cites W2601896814 @default.
- W3139966125 cites W2619851622 @default.
- W3139966125 cites W2625419804 @default.
- W3139966125 cites W2734775567 @default.
- W3139966125 cites W2736460961 @default.
- W3139966125 cites W2745112353 @default.
- W3139966125 cites W2760424869 @default.
- W3139966125 cites W2766922695 @default.
- W3139966125 cites W2769096731 @default.
- W3139966125 cites W2774351255 @default.
- W3139966125 cites W2774787224 @default.
- W3139966125 cites W2787174594 @default.
- W3139966125 cites W2795875233 @default.