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- W3139968950 abstract "Rolf Kemler is a director at the Max-Planck Institute for Immunobiology, Freiburg, and head of the Department of Molecular Embryology. His group has a long-standing interest in the structure and function of the E-cadherin/Catenin cell adhesion complex and of the Wnt/β-Catenin signaling pathway in mouse development. From its inception, Current Opinion in Cell Biology has devoted one of every six issues to a series of reviews on cell–cell contact and extracellular matrix, which have been highly successful. Why does this topic remain so attractive to so many scientists? Two reasons include the biological importance of this field and the periodic opening-up of major new opportunities after the application of new experimental approaches. Every new biology student learns about the fundamental importance of cell–cell and cell–extracellular-matrix adhesion for multicellular organisms. Embryonic patterning, cell migration, sorting and differentiation during development, the subsequent maintenance of differentiated tissue function, and adult tissue remodelling after injury are all controlled by cell adhesion and extracellular signals. Altered adhesion is often a key component of disease processes that range from inflammation to coronary occlusion to cancer. Consequently, besides providing an understanding of basic biological processes, recent research in this field has direct medical implications. Cell–cell and cell–matrix adhesion molecules represent excellent targets for therapy, and rational drug development is no longer a dream." @default.
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- W3139968950 date "2002-10-01" @default.
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- W3139968950 title "Cell-to-cell contact and extracellular matrix - Editorial overview" @default.
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