Matches in SemOpenAlex for { <https://semopenalex.org/work/W3139985867> ?p ?o ?g. }
- W3139985867 abstract "Abstract Hematopoietic stem cells (HSCs) in adult bone marrow (BM) are usually maintained in a state of quiescence. The cellular mechanism coordinating the balance between HSC quiescence and differentiation is not fully understood. Here, we report that galactose-binding lectin-3 (galectin-3; Gal-3) is upregulated by Tie2 or Mpl activation to maintain quiescence. Conditional overexpression of Gal-3 in mouse HSCs under the transcriptional control of Tie2 or Vav1 promoters (Gal-3 Tg) causes cell cycle retardation via induction of p21. Conversely, the cell cycle of long-term repopulating HSCs (LT-HSCs) in Gal-3-deficient (Gal-3 -/- ) mice is accelerated, resulting in their exhaustion. Mechanistically, Gal-3 regulates p21 transcription by forming a complex with Sp1, thus blocking cell cycle entry. These results demonstrate that Gal-3 is a negative regulator of cell-cycling in HSCs and plays a crucial role in adult hematopoiesis to prevent HSC exhaustion." @default.
- W3139985867 created "2021-04-13" @default.
- W3139985867 creator A5000624359 @default.
- W3139985867 creator A5002731323 @default.
- W3139985867 creator A5009176851 @default.
- W3139985867 creator A5012910352 @default.
- W3139985867 creator A5027333997 @default.
- W3139985867 creator A5051675946 @default.
- W3139985867 creator A5053512092 @default.
- W3139985867 creator A5060325837 @default.
- W3139985867 creator A5067087003 @default.
- W3139985867 creator A5068623243 @default.
- W3139985867 creator A5075366948 @default.
- W3139985867 date "2021-04-09" @default.
- W3139985867 modified "2023-10-15" @default.
- W3139985867 title "Indispensable role of Galectin-3 in promoting quiescence of hematopoietic stem cells" @default.
- W3139985867 cites W1782909963 @default.
- W3139985867 cites W1789328091 @default.
- W3139985867 cites W1933705776 @default.
- W3139985867 cites W1952464171 @default.
- W3139985867 cites W1968628080 @default.
- W3139985867 cites W1975479210 @default.
- W3139985867 cites W1977297606 @default.
- W3139985867 cites W1979058918 @default.
- W3139985867 cites W1979935756 @default.
- W3139985867 cites W1992425170 @default.
- W3139985867 cites W1992646856 @default.
- W3139985867 cites W1993216157 @default.
- W3139985867 cites W2004856051 @default.
- W3139985867 cites W2008009288 @default.
- W3139985867 cites W2008223253 @default.
- W3139985867 cites W2009875479 @default.
- W3139985867 cites W2010016099 @default.
- W3139985867 cites W2011745548 @default.
- W3139985867 cites W2018420076 @default.
- W3139985867 cites W2019524333 @default.
- W3139985867 cites W2027610354 @default.
- W3139985867 cites W2029259805 @default.
- W3139985867 cites W2034759328 @default.
- W3139985867 cites W2037144296 @default.
- W3139985867 cites W2041357218 @default.
- W3139985867 cites W2060610551 @default.
- W3139985867 cites W2060930865 @default.
- W3139985867 cites W2061460842 @default.
- W3139985867 cites W2069239976 @default.
- W3139985867 cites W2070793750 @default.
- W3139985867 cites W2081561972 @default.
- W3139985867 cites W2082421146 @default.
- W3139985867 cites W2084156847 @default.
- W3139985867 cites W2084811810 @default.
- W3139985867 cites W2086243699 @default.
- W3139985867 cites W2089353165 @default.
- W3139985867 cites W2091525085 @default.
- W3139985867 cites W2093818708 @default.
- W3139985867 cites W2093958228 @default.
- W3139985867 cites W2094188666 @default.
- W3139985867 cites W2103628876 @default.
- W3139985867 cites W2108019067 @default.
- W3139985867 cites W2117832286 @default.
- W3139985867 cites W2122640456 @default.
- W3139985867 cites W2138790009 @default.
- W3139985867 cites W2139481826 @default.
- W3139985867 cites W2154699417 @default.
- W3139985867 cites W2155755538 @default.
- W3139985867 cites W2157288494 @default.
- W3139985867 cites W2162262059 @default.
- W3139985867 cites W2164662604 @default.
- W3139985867 cites W2166889065 @default.
- W3139985867 cites W2168790441 @default.
- W3139985867 cites W2624346565 @default.
- W3139985867 cites W2766749761 @default.
- W3139985867 cites W2784395700 @default.
- W3139985867 cites W3007233540 @default.
- W3139985867 doi "https://doi.org/10.1038/s41467-021-22346-2" @default.
- W3139985867 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8035175" @default.
- W3139985867 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33837181" @default.
- W3139985867 hasPublicationYear "2021" @default.
- W3139985867 type Work @default.
- W3139985867 sameAs 3139985867 @default.
- W3139985867 citedByCount "7" @default.
- W3139985867 countsByYear W31399858672021 @default.
- W3139985867 countsByYear W31399858672022 @default.
- W3139985867 countsByYear W31399858672023 @default.
- W3139985867 crossrefType "journal-article" @default.
- W3139985867 hasAuthorship W3139985867A5000624359 @default.
- W3139985867 hasAuthorship W3139985867A5002731323 @default.
- W3139985867 hasAuthorship W3139985867A5009176851 @default.
- W3139985867 hasAuthorship W3139985867A5012910352 @default.
- W3139985867 hasAuthorship W3139985867A5027333997 @default.
- W3139985867 hasAuthorship W3139985867A5051675946 @default.
- W3139985867 hasAuthorship W3139985867A5053512092 @default.
- W3139985867 hasAuthorship W3139985867A5060325837 @default.
- W3139985867 hasAuthorship W3139985867A5067087003 @default.
- W3139985867 hasAuthorship W3139985867A5068623243 @default.
- W3139985867 hasAuthorship W3139985867A5075366948 @default.
- W3139985867 hasBestOaLocation W31399858671 @default.
- W3139985867 hasConcept C104317684 @default.
- W3139985867 hasConcept C109159458 @default.
- W3139985867 hasConcept C127561419 @default.
- W3139985867 hasConcept C1491633281 @default.