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- W3140000722 abstract "Objective:To investigate the expression and significance of uteroglobin-related protein 1(UGRP1) in tissues of lung carcinoma.Methods:Immunohistochemistry method was utilized to detect the expression of UGRP1 in 62 cases of lung carcinoma tissues and matching nearby normal tissues.Real time fluorescence quantitative method was utilized to detect the expression of UGRP1 in 20 cases of fresh lung carcinoma tissues and matching nearby normal lung tissues.Results:SABC method immunohistochemistry,the positive expression of UGRP1 was showed in cytoplasm of normal bronchus and bronchiole,in cell nucleus and cytoplasm of lung carcinoma,moreover,mainly in cytoplasm.The positive rate of UGRP1 in lung carcinoma was significantly lower than that in adjacent to normal tissues(P0.05).UGRP1 expression was not concerned with age and sex,but was significantly correlated with histodifferentiation,lymph node metastasis,clinical classification(P0.05).Real time PCR analysis showed that the positive expression of UGRP1mRNA in lung carcinoma was significantly lower than that in matching adjacent to normal lung tissues(P0.05).Conclusion:Down-regulation of UGRP1 expression in lung carcinoma may contribute to genesis and progress of tumor,UGRP1 may be a new candidate suppressor gene." @default.
- W3140000722 created "2021-04-13" @default.
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- W3140000722 date "2009-01-01" @default.
- W3140000722 modified "2023-09-28" @default.
- W3140000722 title "Expression and significance of UGRP1 in lung carcinoma" @default.
- W3140000722 hasPublicationYear "2009" @default.
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