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- W3140000769 abstract "The genetic basis of higher regenerative capacity of fishes, amphibians and reptiles compared to birds and mammals is still poorly understood. Though it is thought to be a result of restructuring in the regulatory network of a static set of genes, we argued that it could be due to the loss of genes essential for regeneration. In the present work, we formulate a bioinformatic approach to systematic search for the such genes. Having identified them, we further investigated one we dubbed “c-Answer”, which encodes a membrane protein, regulating the regeneration of body appendages and the telencephalic development through binding to FGFR and P2Y1 receptors and promoting MAPK/ERK and purinergic signaling. The obtained data suggest that elimination of c-Answer in the ancestors of warm-blooded animals conditioned the decreased activity of at least two signaling pathways, which in turn could contribute to changes in mechanisms that regulate the forebrain development and regeneration." @default.
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- W3140000769 date "2018-01-01" @default.
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- W3140000769 title "Bioinformatic Screening of Genes Present Only in Well Regenerating Vertebrates Reveals Novel FGF and Purinergic Signaling Modulator - C-Answer" @default.
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- W3140000769 doi "https://doi.org/10.2139/ssrn.3232160" @default.
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