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Matches in SemOpenAlex for { <https://semopenalex.org/work/W3140001727> ?p ?o ?g. }

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• W3140001727 abstract "瞄准：在 vitro 在导致 oridonin 的 MCF-7human 乳癌房间 apoptosis 学习 caspase-3-independent 机制。方法：oridonintreated MCF-7 房间的生存能力被 MTT (thiazole 蓝色) 测量试金。有压缩原子核的 Apoptotic 房间被阶段对比显微镜学设想。Nucleosomal DNA 破碎是由统帅玫瑰胶化电气泳动的 assayed。apoptotic 比率被决定由喂奶脱氢酶试金。房间周期引申 andmitochondrial 膜潜力被流动 cytometric 分析测量。Bax， Bcl-2， caspase-3， caspase-9，热吃惊蛋白质(Hsp ) 90， p53， p-p53， p21，(自动数据处理核糖) Poly，聚合酶(PARP ) ，和激活 caspase 的 DNase (ICAD ) 蛋白质表情的禁止者被西方的污点分析检测。结果：Oridonin 在一个时间依赖者和剂量依赖者举止禁止了房间生长。房间周期被改变通过起来 p53 和 p21 蛋白质表情的规定。Pancaspase inhibitorZ-VAD-fmk 和 calpain 禁止者 II 两个都减少了房间死亡比率。Nucleosomal DNA 破碎并且下面 DeltaPhimit 的规定在导致 oridonin 的 MCF-7 房间 apoptosis 被检测，它涉及一条 postmitochondrial caspase-9-dependent 小径。减少的 Bcl-2 和 Hsp90expression 层次和 p21 表示层次断然与 phosphorylated p53 phosphorylation 的提高的层次被相关。而且， PARP 部分被劈开 bycalpain 而非由 capase-3。结论：DNA 损坏在线粒体陆地 caspase-9 小径以及调停 p53 的房间周期拘捕挑起了引申，但是不与在导致 oridonin 的 MCF-7 房间的 caspase-3activity 有关。" @default.
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• W3140001727 date "2007-01-01" @default.
• W3140001727 modified "2023-09-23" @default.
• W3140001727 title "P53-mediated cell cycle arrest and apoptosis through a caspase-3- independent, but caspase-9-dependent pathway in oridonin-treated MCF-7 human breast cancer cells" @default.
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