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• W3140036767 abstract "瞄准：调查角色在瘤坏死 factor-alpha (TNF-alpha ) 的倡导者的单个核苷酸多型性(SNP ) 在在一张新西兰人口的煽动性的肠疾病(IBD ) 的风险的基因玩，在国际研究的上下文。方法：从有 Crohn 的疾病(CD ) 的 388 个病人的 DNA 样品， 405 ulcerative (UC ) ， 27 不确定的大肠炎(IC ) 和 201 随机选择的控制从坎特伯雷，新西兰在 TNF-alpha 受体为 3 普通多型性被屏蔽：-238 G 右箭头 A， -308 G 右箭头 A 和 -857C 权利箭头 T，用 TaqmanR 试金。元分析在在从另外的出版研究与那相结合的这些多型性上获得的数据上被执行。结果：带 -308 G/A 等位基因的个人有一显著地(或 = 1.91， c2 = 17.36， P < 0.0001 ) 平底锅大肠炎的增加的风险，和 1.57 褶层增加了风险(或 = 1.57， c2 = 4.34， P = 0.037 ) 在 UC 要求肠切除术。带 -857 C/T 变体减少了回肠结肠 CD 的风险(或 = 0.56， c2 = 4.32， P = 0.037 ) ，并且对肠切除术的需要(或 = 0.59， c2 = 4.85， P = 0.028 ) 。UC 的风险在是在诊断的吸烟者的个人被减少，(或 = 0.48， c2 = 4.86， P = 0.028 ) 。结论：TNF-alpha 是知道在煽动性的反应起一个作用的关键 cytokine，并且为基因的地点在染色体 6p21 上在 IBD3 区域被发现，知道为 IBD 与增加的风险被联系。在 TNF-alpha 倡导者的 -308 G/A SNP 是功能的，并且可以部分地说明与 IBD3 genomic 区域联系的增加的 UC 风险。-857 C/T SNP 可以减少在某些组的 IBD 风险。药或 nutrigenomic 途径可能为有如此的影响遗传型的个人是合乎需要的。" @default.
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• W3140036767 date "2008-01-01" @default.
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• W3140036767 title "Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk" @default.
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