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- W3140052257 abstract "Objective:To identify the function of the 5′-flank upstream regulation region of human CD226 gene.Methods:The upstream regulation region of CD226 was cloned by PCR and ligated into pGL3 vector. Then the vector was transfected into Jurkat cell and luciferase activity was detected after 48 h culture.Results:CD226 gene may have two promoters, P1 and P2,which were located at the region of -843--319 bp and +1-+181 bp respectively, and PMA can up-regulate P1 while down-regulate P2. Both P1 and P2 can be up-regulated by A23187, especially P2.Conclusion:CD226 gene may have two promoters, and PMA and A23187 can regulate CD226 promoter activity in the similar pattern of protein level." @default.
- W3140052257 created "2021-04-13" @default.
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- W3140052257 date "2005-01-01" @default.
- W3140052257 modified "2023-09-23" @default.
- W3140052257 title "Identification of 5-flank upstream regulation region of CD226" @default.
- W3140052257 hasPublicationYear "2005" @default.
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