FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3140065362> ?p ?o ?g. }

• W3140065362 endingPage "108929" @default.
• W3140065362 startingPage "108929" @default.
• W3140065362 abstract "The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase that controls cell cycle transitions. Its regulation by the spindle assembly checkpoint (SAC) is coordinated with the attachment of sister chromatids to the mitotic spindle. APC/C SUMOylation on APC4 ensures timely anaphase onset and chromosome segregation. To understand the structural and functional consequences of APC/C SUMOylation, we reconstituted SUMOylated APC/C for electron cryo-microscopy and biochemical analyses. SUMOylation of the APC/C causes a substantial rearrangement of the WHB domain of APC/C's cullin subunit (APC2WHB). Although APC/CCdc20 SUMOylation results in a modest impact on normal APC/CCdc20 activity, repositioning APC2WHB reduces the affinity of APC/CCdc20 for the mitotic checkpoint complex (MCC), the effector of the SAC. This attenuates MCC-mediated suppression of APC/CCdc20 activity, allowing for more efficient ubiquitination of APC/CCdc20 substrates in the presence of the MCC. Thus, SUMOylation stimulates the reactivation of APC/CCdc20 when the SAC is silenced, contributing to timely anaphase onset." @default.
• W3140065362 created "2021-04-13" @default.
• W3140065362 creator A5007100166 @default.
• W3140065362 creator A5019554177 @default.
• W3140065362 creator A5024806488 @default.
• W3140065362 creator A5029663747 @default.
• W3140065362 creator A5051279095 @default.
• W3140065362 creator A5052770600 @default.
• W3140065362 creator A5054213383 @default.
• W3140065362 creator A5062709180 @default.
• W3140065362 creator A5071470775 @default.
• W3140065362 creator A5084533174 @default.
• W3140065362 creator A5089377691 @default.
• W3140065362 date "2021-03-01" @default.
• W3140065362 modified "2023-10-16" @default.
• W3140065362 title "Molecular mechanisms of APC/C release from spindle assembly checkpoint inhibition by APC/C SUMOylation" @default.
• W3140065362 cites W1799534295 @default.
• W3140065362 cites W1881319148 @default.
• W3140065362 cites W1964731656 @default.
• W3140065362 cites W1969616198 @default.
• W3140065362 cites W1969873424 @default.
• W3140065362 cites W1978850887 @default.
• W3140065362 cites W1980487829 @default.
• W3140065362 cites W1997764447 @default.
• W3140065362 cites W2008174897 @default.
• W3140065362 cites W2018711267 @default.
• W3140065362 cites W2021992655 @default.
• W3140065362 cites W2029158215 @default.
• W3140065362 cites W2029875848 @default.
• W3140065362 cites W2033339495 @default.
• W3140065362 cites W2039741753 @default.
• W3140065362 cites W2043927273 @default.
• W3140065362 cites W2053851813 @default.
• W3140065362 cites W2061571202 @default.
• W3140065362 cites W2066331228 @default.
• W3140065362 cites W2068853021 @default.
• W3140065362 cites W2078870259 @default.
• W3140065362 cites W2088357489 @default.
• W3140065362 cites W2091196019 @default.
• W3140065362 cites W2103203123 @default.
• W3140065362 cites W2104458086 @default.
• W3140065362 cites W2108423991 @default.
• W3140065362 cites W2120772351 @default.
• W3140065362 cites W2124026197 @default.
• W3140065362 cites W2133435867 @default.
• W3140065362 cites W2137932686 @default.
• W3140065362 cites W2154915448 @default.
• W3140065362 cites W2168322321 @default.
• W3140065362 cites W2287979113 @default.
• W3140065362 cites W2343854987 @default.
• W3140065362 cites W2404252289 @default.
• W3140065362 cites W2416333604 @default.
• W3140065362 cites W2489412446 @default.
• W3140065362 cites W2490844245 @default.
• W3140065362 cites W2508401504 @default.
• W3140065362 cites W2512450462 @default.
• W3140065362 cites W2734356283 @default.
• W3140065362 cites W2769618080 @default.
• W3140065362 cites W2785577391 @default.
• W3140065362 cites W2791068518 @default.
• W3140065362 cites W2792436374 @default.
• W3140065362 cites W2898104208 @default.
• W3140065362 cites W2899714098 @default.
• W3140065362 cites W2971054316 @default.
• W3140065362 cites W3016362311 @default.
• W3140065362 doi "https://doi.org/10.1016/j.celrep.2021.108929" @default.
• W3140065362 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8028313" @default.
• W3140065362 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33789095" @default.
• W3140065362 hasPublicationYear "2021" @default.
• W3140065362 type Work @default.
• W3140065362 sameAs 3140065362 @default.
• W3140065362 citedByCount "11" @default.
• W3140065362 countsByYear W31400653622021 @default.
• W3140065362 countsByYear W31400653622022 @default.
• W3140065362 countsByYear W31400653622023 @default.
• W3140065362 crossrefType "journal-article" @default.
• W3140065362 hasAuthorship W3140065362A5007100166 @default.
• W3140065362 hasAuthorship W3140065362A5019554177 @default.
• W3140065362 hasAuthorship W3140065362A5024806488 @default.
• W3140065362 hasAuthorship W3140065362A5029663747 @default.
• W3140065362 hasAuthorship W3140065362A5051279095 @default.
• W3140065362 hasAuthorship W3140065362A5052770600 @default.
• W3140065362 hasAuthorship W3140065362A5054213383 @default.
• W3140065362 hasAuthorship W3140065362A5062709180 @default.
• W3140065362 hasAuthorship W3140065362A5071470775 @default.
• W3140065362 hasAuthorship W3140065362A5084533174 @default.
• W3140065362 hasAuthorship W3140065362A5089377691 @default.
• W3140065362 hasBestOaLocation W31400653621 @default.
• W3140065362 hasConcept C104317684 @default.
• W3140065362 hasConcept C107888121 @default.
• W3140065362 hasConcept C134459356 @default.
• W3140065362 hasConcept C1491633281 @default.
• W3140065362 hasConcept C171350616 @default.
• W3140065362 hasConcept C175732170 @default.
• W3140065362 hasConcept C185592680 @default.
• W3140065362 hasConcept C192838845 @default.
• W3140065362 hasConcept C25602115 @default.
• W3140065362 hasConcept C29537977 @default.

• next