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• W3140152496 abstract "Analysis of molecular pathway activation is the recent instrument that helps to quantize activities of various intracellular signaling, structural, DNA synthesis and repair, and biochemical processes. This may have a deep impact in fundamental research, bioindustry, and medicine. Unlike gene ontology analyses and numerous qualitative methods that can establish whether a pathway is affected in principle, the quantitative approach has the advantage of exactly measuring the extent of a pathway up/downregulation. This results in emergence of a new generation of molecular biomarkers—pathway activation levels, which reflect concentration changes of all measurable pathway components. The input data can be the high-throughput proteomic or transcriptomic profiles, and the output numbers take both positive and negative values and positively reflect overall pathway activation. Due to their nature, the pathway activation levels are more robust biomarkers compared to the individual gene products/protein levels. Here, we review the current knowledge of the quantitative gene expression interrogation methods and their applications for the molecular pathway quantization. We consider enclosed bioinformatic algorithms and their applications for solving real-world problems. Besides a plethora of applications in basic life sciences, the quantitative pathway analysis can improve molecular design and clinical investigations in pharmaceutical industry, can help finding new active biotechnological components and can significantly contribute to the progressive evolution of personalized medicine. In addition to the theoretical principles and concepts, we also propose publicly available software for the use of large-scale protein/RNA expression data to assess the human pathway activation levels." @default.
• W3140152496 created "2021-04-13" @default.
• W3140152496 creator A5008472454 @default.
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• W3140152496 creator A5077749610 @default.
• W3140152496 creator A5079640410 @default.
• W3140152496 date "2021-01-01" @default.
• W3140152496 modified "2023-10-12" @default.
• W3140152496 title "Using proteomic and transcriptomic data to assess activation of intracellular molecular pathways" @default.
• W3140152496 cites W1480379639 @default.
• W3140152496 cites W1489807667 @default.
• W3140152496 cites W1524218692 @default.
• W3140152496 cites W1527265103 @default.
• W3140152496 cites W1541083168 @default.
• W3140152496 cites W1873477530 @default.
• W3140152496 cites W1883695122 @default.
• W3140152496 cites W1897652401 @default.
• W3140152496 cites W1963396472 @default.
• W3140152496 cites W1970156673 @default.
• W3140152496 cites W1974436271 @default.
• W3140152496 cites W1981972440 @default.
• W3140152496 cites W1991735821 @default.
• W3140152496 cites W1991944021 @default.
• W3140152496 cites W1993302385 @default.
• W3140152496 cites W1995077413 @default.
• W3140152496 cites W1995396223 @default.
• W3140152496 cites W1995819749 @default.
• W3140152496 cites W2001620484 @default.
• W3140152496 cites W2006138378 @default.
• W3140152496 cites W2008264512 @default.
• W3140152496 cites W2009276427 @default.
• W3140152496 cites W2009405916 @default.
• W3140152496 cites W2011480812 @default.
• W3140152496 cites W2014949551 @default.
• W3140152496 cites W2015421127 @default.
• W3140152496 cites W2018838463 @default.
• W3140152496 cites W2021505095 @default.
• W3140152496 cites W2030120875 @default.
• W3140152496 cites W2035436598 @default.
• W3140152496 cites W2038625523 @default.
• W3140152496 cites W2038963685 @default.
• W3140152496 cites W2042729651 @default.
• W3140152496 cites W2045492227 @default.
• W3140152496 cites W2046024621 @default.
• W3140152496 cites W2051372177 @default.
• W3140152496 cites W2054789404 @default.
• W3140152496 cites W2060460012 @default.
• W3140152496 cites W2064397275 @default.
• W3140152496 cites W2074640340 @default.
• W3140152496 cites W2075836195 @default.
• W3140152496 cites W2076394567 @default.
• W3140152496 cites W2077491506 @default.
• W3140152496 cites W2079517684 @default.
• W3140152496 cites W2084037162 @default.
• W3140152496 cites W2084561418 @default.
• W3140152496 cites W2085080141 @default.
• W3140152496 cites W2086936470 @default.
• W3140152496 cites W2093814864 @default.
• W3140152496 cites W2096330673 @default.
• W3140152496 cites W2096766502 @default.
• W3140152496 cites W2100731931 @default.
• W3140152496 cites W2100980426 @default.
• W3140152496 cites W2101625777 @default.
• W3140152496 cites W2105665764 @default.
• W3140152496 cites W2107433421 @default.
• W3140152496 cites W2107989442 @default.
• W3140152496 cites W2109912704 @default.
• W3140152496 cites W2110280725 @default.
• W3140152496 cites W2110687686 @default.
• W3140152496 cites W2114438891 @default.
• W3140152496 cites W2119028181 @default.
• W3140152496 cites W2119921227 @default.
• W3140152496 cites W2120865735 @default.
• W3140152496 cites W2124140824 @default.
• W3140152496 cites W2127012419 @default.
• W3140152496 cites W2127401140 @default.
• W3140152496 cites W2133465414 @default.
• W3140152496 cites W2134389439 @default.
• W3140152496 cites W2134394193 @default.
• W3140152496 cites W2134787419 @default.
• W3140152496 cites W2135230352 @default.
• W3140152496 cites W2136609880 @default.
• W3140152496 cites W2137874618 @default.
• W3140152496 cites W2138482047 @default.
• W3140152496 cites W2141799119 @default.
• W3140152496 cites W2142302575 @default.
• W3140152496 cites W2143897439 @default.
• W3140152496 cites W2148101811 @default.
• W3140152496 cites W2149199536 @default.
• W3140152496 cites W2152239989 @default.
• W3140152496 cites W2154972152 @default.
• W3140152496 cites W2158217645 @default.
• W3140152496 cites W2158485828 @default.

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