FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3140168552> ?p ?o ?g. }

• W3140168552 abstract "Abstract Serotonin is critically involved in flexible decision-making, yet the preponderance of evidence comes from non-human studies. Many insights about the serotonin’s function have come from the technique of dietary acute tryptophan depletion (ATD). However, it is unclear whether ATD modulates choice behavior during probabilistic reversal learning (PRL), a widely used model of behavioral flexibility with significant translational and clinical value. To determine whether ATD affects latent choice tendencies, we applied computational models of reinforcement learning to PRL data from healthy human volunteers (n = 62; 29 females) who had received either ATD or placebo in a randomized, double-blind, placebo-controlled procedure. A secondary objective was to ascertain how model parameters related to clinically relevant self-report questionnaires. ATD did not affect the updating (“learning rates”) or deployment (“reinforcement sensitivity”) of value representations driving choice. However, ATD increased “stimulus stickiness”, the tendency to choose a previously chosen visual stimulus again, regardless of reinforcement—a pattern seen in stimulant use disorder (SUD). Greater subclinical obsessive–compulsive symptoms were associated with lower stimulus stickiness, a pattern seen in clinically diagnosed obsessive–compulsive disorder (OCD). Low reinforcement sensitivity was instead related to intolerance of uncertainty and symptoms of depression and anxiety. Individuals with higher trait impulsivity showed lower reward and higher punishment learning rates, which parallels findings in SUD. Collectively, these results point to a role for serotonin in compulsive tendencies. They underscore the utility of computational modelling in illuminating the microstructure of behavior, which could point towards new markers of vulnerability to psychopathology." @default.
• W3140168552 created "2021-04-13" @default.
• W3140168552 creator A5009234799 @default.
• W3140168552 creator A5017105234 @default.
• W3140168552 creator A5020886846 @default.
• W3140168552 creator A5033436625 @default.
• W3140168552 creator A5040247083 @default.
• W3140168552 creator A5041563576 @default.
• W3140168552 creator A5042361334 @default.
• W3140168552 creator A5057523747 @default.
• W3140168552 creator A5068981431 @default.
• W3140168552 date "2021-04-06" @default.
• W3140168552 modified "2023-10-16" @default.
• W3140168552 title "Perseverative behavior under uncertainty is enhanced by tryptophan depletion but diminished with subclinical obsessive–compulsive symptoms" @default.
• W3140168552 cites W1951616283 @default.
• W3140168552 cites W1991856477 @default.
• W3140168552 cites W1995051494 @default.
• W3140168552 cites W1997016612 @default.
• W3140168552 cites W2007022291 @default.
• W3140168552 cites W2010147753 @default.
• W3140168552 cites W2011826549 @default.
• W3140168552 cites W2013293748 @default.
• W3140168552 cites W2023590101 @default.
• W3140168552 cites W2023687307 @default.
• W3140168552 cites W2032778442 @default.
• W3140168552 cites W2033938510 @default.
• W3140168552 cites W2034531314 @default.
• W3140168552 cites W2039051284 @default.
• W3140168552 cites W2041300466 @default.
• W3140168552 cites W2041529027 @default.
• W3140168552 cites W2051045414 @default.
• W3140168552 cites W2051068515 @default.
• W3140168552 cites W2055810716 @default.
• W3140168552 cites W2059569317 @default.
• W3140168552 cites W2061795745 @default.
• W3140168552 cites W2063601827 @default.
• W3140168552 cites W2066018239 @default.
• W3140168552 cites W2069947117 @default.
• W3140168552 cites W2072467374 @default.
• W3140168552 cites W2075752735 @default.
• W3140168552 cites W2083058253 @default.
• W3140168552 cites W2085838527 @default.
• W3140168552 cites W2088935764 @default.
• W3140168552 cites W2093106172 @default.
• W3140168552 cites W2095629588 @default.
• W3140168552 cites W2095955857 @default.
• W3140168552 cites W2096107166 @default.
• W3140168552 cites W2098120777 @default.
• W3140168552 cites W2107665951 @default.
• W3140168552 cites W2116892542 @default.
• W3140168552 cites W2119259385 @default.
• W3140168552 cites W2131803813 @default.
• W3140168552 cites W2146676986 @default.
• W3140168552 cites W2150280168 @default.
• W3140168552 cites W2153988153 @default.
• W3140168552 cites W2154966614 @default.
• W3140168552 cites W2158282570 @default.
• W3140168552 cites W2158770881 @default.
• W3140168552 cites W2163274894 @default.
• W3140168552 cites W2170902703 @default.
• W3140168552 cites W2170969968 @default.
• W3140168552 cites W2171090495 @default.
• W3140168552 cites W2437388468 @default.
• W3140168552 cites W2479411493 @default.
• W3140168552 cites W2522716651 @default.
• W3140168552 cites W2567996319 @default.
• W3140168552 cites W2568577966 @default.
• W3140168552 cites W2577537660 @default.
• W3140168552 cites W2602422862 @default.
• W3140168552 cites W2767152246 @default.
• W3140168552 cites W2892955830 @default.
• W3140168552 cites W2911799269 @default.
• W3140168552 cites W2949941589 @default.
• W3140168552 cites W2953994914 @default.
• W3140168552 cites W2957704534 @default.
• W3140168552 cites W2978033196 @default.
• W3140168552 cites W2999677295 @default.
• W3140168552 cites W3001584961 @default.
• W3140168552 cites W3008435479 @default.
• W3140168552 cites W3008607971 @default.
• W3140168552 cites W3090093514 @default.
• W3140168552 cites W3101476051 @default.
• W3140168552 cites W3106920291 @default.
• W3140168552 cites W3122554617 @default.
• W3140168552 cites W3152135373 @default.
• W3140168552 cites W4249731213 @default.
• W3140168552 cites W4377077026 @default.
• W3140168552 doi "https://doi.org/10.1101/2021.04.05.437619" @default.
• W3140168552 hasPublicationYear "2021" @default.
• W3140168552 type Work @default.
• W3140168552 sameAs 3140168552 @default.
• W3140168552 citedByCount "0" @default.
• W3140168552 crossrefType "posted-content" @default.
• W3140168552 hasAuthorship W3140168552A5009234799 @default.
• W3140168552 hasAuthorship W3140168552A5017105234 @default.
• W3140168552 hasAuthorship W3140168552A5020886846 @default.
• W3140168552 hasAuthorship W3140168552A5033436625 @default.
• W3140168552 hasAuthorship W3140168552A5040247083 @default.
• W3140168552 hasAuthorship W3140168552A5041563576 @default.
• W3140168552 hasAuthorship W3140168552A5042361334 @default.

• next