Matches in SemOpenAlex for { <https://semopenalex.org/work/W3140207009> ?p ?o ?g. }
- W3140207009 abstract "Several studies show that childhood and adulthood asthma and its symptoms can be modulated through epigenetic modifications. Epigenetic changes are inheritable modifications that can modify the gene expression without changing the DNA sequence. The most common epigenetic alternations consist of DNA methylation and histone modifications. How these changes lead to asthmatic phenotype or promote the asthma features, in particular by immune pathways regulation, is an understudied topic. Since external effects, like exposure to tobacco smoke, air pollution, and drugs, influence both asthma development and the epigenome, elucidating the role of epigenetic changes in asthma is of great importance. This review presents available evidence on the epigenetic process that drives asthma genes and pathways, with a particular focus on DNA methylation, histone methylation, and acetylation. We gathered and assessed studies conducted in this field over the past two decades. Our study examined asthma in different aspects and also shed light on the limitations and the important factors involved in the outcomes of the studies. To date, most of the studies in this area have been carried out on DNA methylation. Therefore, the need for diagnostic and therapeutic applications through this molecular process calls for more research on the histone modifications in this disease." @default.
- W3140207009 created "2021-04-13" @default.
- W3140207009 creator A5007088631 @default.
- W3140207009 creator A5026836051 @default.
- W3140207009 creator A5031388913 @default.
- W3140207009 creator A5043929994 @default.
- W3140207009 date "2021-03-29" @default.
- W3140207009 modified "2023-10-18" @default.
- W3140207009 title "A review of epigenetic changes in asthma: methylation and acetylation" @default.
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