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- W3140217221 abstract "Objective To investigate that ginsenosides (GS) promotes proliferation of hematopoietic cells by virtue of the intracellular signaling pathway. Methods Three human megakaryocytic cell lines and Northern blot analysis, electrophoretic mobility shift assay (EMSA), antibody gel supershift assay and UVradiation crosslinking were used. Results After treatment with GS, GATA2 mRNA levels in CHRF288, Meg01 and MO7e cells were increased by 1.84-,2.43-and 1.52- fold, respectively, while GATA1 mRNA levels remained as low as pretreatment. GATA binding activities were elevated in all the three GS treated cell lines. The GATA binding complex appeared as a band with an approximate molecular weight of 50000 corresponding to the size of GATA2 protein. Conclusions The intracellular signaling pathway initiated by GS was involved in transcription factor GATA2. GATA2 might play the key role in the GS induced upregulation of megakaryopoiesis." @default.
- W3140217221 created "2021-04-13" @default.
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- W3140217221 date "1999-01-01" @default.
- W3140217221 modified "2023-09-23" @default.
- W3140217221 title "The intracellular signaling pathway initiated by ginsenosides in hematopoietic cells" @default.
- W3140217221 hasPublicationYear "1999" @default.
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