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- W3140221468 abstract "Biologics 包括 monoclonal 抗体(mAbs ) 和象 cytokines 和生长荷尔蒙那样的另外的治疗学的蛋白质，与小分子相比有唯一的特征。这篇论文为阶段 II/III 临床的试用从一个机械学的观点，为 first-in-human (FIH ) 的剂量学习的开始的决心，和 dosing 政体优化从 biologics 的 pharmacokinetics (PK ) 的概述开始。随后，典型临床的药理学发出相应小径因为 biologics 开发被总结，包括在特定的人口的药药相互作用， QTc 延伸， immunogenicity，和研究。在 biologics，他们的 pharmacokinetic 和 pharmacodynamic 特征，和相应临床的药理学策略的分子的结构之间的关系在一张图解的图被总结并且描绘。" @default.
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- W3140221468 date "2012-01-01" @default.
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- W3140221468 title "Clinical pharmacology considerations in biologics development" @default.
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